This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Selective Correlation Based Knowledge Distillation for Ground Reaction Force Estimation. [PDF]
Jeon ES +5 more
europepmc +1 more source
Two‐photon polymerization enables high‐resolution microfabrication, but performing alignment when printing multiple structures is difficult. Here, we present a fast, robust, and open‐source protocol for automated alignment on Nanoscribe systems. Achieving ≈0.4 μm accuracy in under 5 s, our protocol reduces time and error in multimaterial printing. This
Daniel Maher +4 more
wiley +1 more source
Morphology-aware distillation for lightweight retinal vessel segmentation across fundus photography and OCT angiography. [PDF]
Shu H +10 more
europepmc +1 more source
LLM‐Based Scientific Assistants for Knowledge Extraction: Which Design Choices Matter?
A comprehensive framework for optimizing Large Language Models in domain‐specific applications is introduced. The LLM Playground integrates Prompt Engineering, knowledge augmentation, and advanced reasoning strategies to enable systematic comparison of architectures and base models.
David Exler +7 more
wiley +1 more source
Cross-Architecture Knowledge Distillation for Histopathological Image Analysis. [PDF]
Boudissa S +3 more
europepmc +1 more source
AI Powered Biobanks From Static Archives to Dynamic Discovery Engines
Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin +5 more
wiley +1 more source
"A Change in Culture From It Being an Optional Extra to an Integral Part of Education"-Teacher's Experiences of Teaching Relationships and Sexuality Education (RSE) to Learners With Severe/Profound Intellectual Disabilities in the Republic of Ireland. [PDF]
Connolly L, O'Mahony K, Scully C.
europepmc +1 more source
Phonons‐informed machine‐learning predictive models are propitious for reproducing thermal effects in computational materials science studies. Machine learning (ML) methods have become powerful tools for predicting material properties with near first‐principles accuracy and vastly reduced computational cost.
Pol Benítez +4 more
wiley +1 more source

