Results 21 to 30 of about 5,710,845 (340)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

open access: yesFEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo   +6 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Mathematics and Science Courses Required or Recommended for Admission into Engineering and Engineering Technology Programs at Massachusetts Institutions of Higher Education

open access: yesNonpartisan Education Review, 2019
This survey of the high school mathematics and science requirements for admission to the 11 colleges of engineering in Massachusetts in 2003 provides interesting facts in Tables 3 and 4.
Center for Teaching and Learning
doaj  

Teaching Democracy by Teaching Supernaturalism [PDF]

open access: yesReligions, 2019
This paper analyzes critiques of the supernatural by John Dewey, a celebrated American philosopher. Dewey rejected the supernatural on scientific and cosmological grounds, but his most significant critique was made on political grounds. In A Common Faith and other writings, Dewey suggests that supernaturalism erodes democracy by promoting a dualism ...
openaire   +4 more sources

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash   +3 more
wiley   +1 more source

Methods for working with problem residents in medical physics residency education

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Medical physics residency training programs may occasionally encounter residents requiring additional intervention beyond normal training efforts. In the literature, these residents are referred to as “problem” residents. While the physician literature on the subject is valuable, this paper specifically focuses on dealing with a problem ...
Christopher J. Watchman, Dandan Zheng
wiley   +1 more source

Responsive Math Teaching Model [PDF]

open access: yes, 2021
The Responsive Math Teaching (RMT) Model breaks high-quality math teaching down into six core components: Plan: Select or adapt an appropriate task, identify the mathematical goal(s), and anticipate possible solution paths and challenges.
Responsive Math Teaching Project
core   +1 more source

Assessment of a medical physics educational program for science teachers

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Medical physics is a fulfilling profession where physics is applied to advance human health. However, many are uninformed of the role of physicists in medicine, and students are unaware of this career pathway. This study presents a pilot 1‐year program for science teachers to learn about physics in medicine and share with students
Ashley J. Cetnar   +2 more
wiley   +1 more source

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