Results 31 to 40 of about 436,055 (313)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

INVESTIGATING THE TYPES OF CODE SWITCHING IN LANGUAGE TEACHING INSTRUCTION IN EFL CLASS OF SMA I NEGERI SAMARINDA

open access: yesCaLLs: Journal of Culture, Arts, Literature, and Linguistics, 2018
Not only as a language interference, code switching was able to be used as one of language teaching strategy. This study investigated the types of code switching used by a teacher in language teaching instruction in EFL class of SMA I Negeri Samarinda ...
Desy Rusmawaty
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

La glottodidattica individuale

open access: yesEducazione Linguistica Language Education, 2017
The paper proposes a first of its kind investigation on individual language teaching context. Given its original and uncommon nature, the main objective is to outline a preliminary characterisation of the topic.
Gardin, Giacomo
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Teaching Formal Methods in Context

open access: yes, 2004
The Software Engineering Programme at Oxford teaches formal methods as an integral part of its programme of professional education in software engineering. This paper explains how the methods are taught—in the context of emerging trends in software development, and in the context of existing practice—and how their use is promoted through course design ...
Jim Davies   +2 more
openaire   +4 more sources

Developing Accomplished Teaching and Teachers [PDF]

open access: yes, 2010
This paper discusses the question of the development of accomplished teachers and teaching in Scotland and examines a number of emerging issues including the definition of accomplished teaching, the enhancement of teaching quality, the role of ...
Forde, C.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Politeness and verbal language education: reflections on racing comunicativa, interpersonal game and normativity

open access: yesFilologia e Linguística Portuguesa, 2015
From a practical perspective, this chapter seeks to reflect on the need to incorporate verbal politeness in the teaching of the Portuguese language, both oral and written modes, considering how the interpersonal interaction in various social contexts is ...
Leonor Lopes Fávero   +1 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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