Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The impact of e-learning in the education in the information society
The article says about the features of the nurturing activities in the information society. Electronic educational resources should be directed towards new educational results.
Trubina Irina I., Braines Anna A.
doaj +1 more source
Conditions for creating a balance between learning styles on the example of the material of the discipline “Ecological Chemistry and Environmental Monitoring” [PDF]
Aspects of learning styles modelled on R. Felder and B. Soloman are discussed in detail. The results of the study of the educational advantages of students of Kryvyi Rih State Pedagogical University of the speciality “014 Secondary education (Chemistry)”
Kolchanova Mariia +2 more
doaj +1 more source
Aims and methods in teaching typewriting [PDF]
Thesis (Ed.M.)--Boston University.
Bartick, Mary Catherine
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Analysis of How Active Centers Identify and Cultivate Preschool Children's Talent Based on the Lived Experience of Educators and Officials in Karaj [PDF]
The objective of the present study was to examine the lived experiences of educators and officials of talent centers in the identification and development of preschool children's talents.
Samaneh Zanganeh +2 more
doaj +1 more source
Listening skill is one of the essential aspects of Arabic learning. There was no teaching material for Arabic listening skills in the form of books at Kulliyyatul Muallimin al-Islamiyyah (KMI) Gontor which lead to an imbalance of harmonies among four ...
Fairuz Subakir +4 more
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Methods used in teaching wrestling to the blind [PDF]
Thesis (Ed.M.)--Boston ...
Wawrzaszek, Frank Joseph
core +1 more source

