Results 111 to 120 of about 90,090 (290)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose Patients with body weights close to or above 400 lbs present unique challenges in radiation therapy since the weight limit of most treatment couches decreases as the couch‐top extends toward the treatment gantry. The purpose of this work was to develop a small footprint couch‐top support platform to safely perform image‐guided ...
Huixiao Chen   +5 more
wiley   +1 more source

Global linear and nonlinear gyrokinetic simulations of tearing modes

open access: yesNuclear Fusion
To better understand multi-scale interactions between global tearing modes and microturbulence in the Madison Symmetric Torus (MST) reversed-field pinch (RFP), the global gyrokinetic code Gene is modified to describe global tearing mode instability via a
T. Jitsuk   +6 more
doaj   +1 more source

Investigation of Tearing Mode Stability Near Ideal Stability Boundaries Via Asymptotic Matching Techniques [PDF]

open access: yesarXiv
A number of improvements to the TJ toroidal tearing mode code [Phys. Plasmas 31, 102507 (2024)] are documented. The TJ code is also successfully benchmarked against the STRIDE toroidal tearing mode code [Phys. Plasmas 25, 082502 (2018)]. Finally, the new capabilities of the TJ code are used to investigate the stability of tearing modes in tokamak ...
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Clinical commissioning of an adaptive radiotherapy platform: Results and recommendations

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Online adaptive radiotherapy platforms present a unique challenge for commissioning as guidance is lacking and specialized adaptive equipment, such as deformable phantoms, are rare. We designed a novel adaptive commissioning process consisting of end‐to‐end tests using standard clinical resources.
Kelly Kisling   +5 more
wiley   +1 more source

Influence of alloying elements on hot tearing susceptibility of Mg–Zn alloys based on thermodynamic calculation and experimental

open access: yesJournal of Magnesium and Alloys, 2018
Based on the hot tearing index |∆T/∆(fs)0.5| recently proposed by Kou and the thermodynamic calculations of Pandat software, Al, Cu, and Mn elements were picked up and their influence on hot tearing susceptibility of Mg–xZn (x = 6, 8, 10, wt%) alloys was
Zhenzhen Yang   +6 more
doaj  

Collisionless Tearing Instability in Relativistic Nonthermal Pair Plasma and Its Application to MHD Turbulence

open access: yesThe Astrophysical Journal
Collisionless tearing instability with a power-law distribution function in a relativistic pair plasma with a guide field is studied. When the current sheet is supported by plasma pressure, the tearing mode is suppressed as the particle spectrum hardens.
Ivan Demidov, Yuri Lyubarsky
doaj   +1 more source

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