Results 121 to 130 of about 442,895 (373)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Nonlinear evolution of weakly coupled double tearing modes with equilibrium sheared toroidal flow

Nuclear Fusion
The nonlinear evolution of weakly coupled double tearing modes (DTMs) with and without sheared toroidal flow is systematically investigated with the three-dimensional, toroidal-geometry, and nonlinear magneto-hydro-dynamics code CLT. Due to the explosive
Y. Y. Ying, Z. M. Wang, Y. Y. Zhang, W. Zhang, X. D. Meng, Z. W. Ma   +5 more
doaj   +1 more source

Can prominences form in current sheets [PDF]

Two-dimensional numerical simulations of the formation of cold condensations in a vertical current sheet have been performed using the radiative, resistive MHD equations with line-tied boundary conditions at one end of the sheet.
Forbes, T. G., Malherbe, J. M.
core   +1 more source

Diagnostic Accuracy of Magnetic Resonance Imaging (MRI) in the Detection of Anterior Cruciate Ligament (ACL) Tear, keeping Arthroscopic Findings as Gold Standard

, 2023
Ayesha Javaid, Wajeeha Anam, Hidayat Ullah, Tayyeba Afzal, Rashid Mahmood, Salah ud din Balooch   +5 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Global linear and nonlinear gyrokinetic simulations of tearing modes

Nuclear Fusion
To better understand multi-scale interactions between global tearing modes and microturbulence in the Madison Symmetric Torus (MST) reversed-field pinch (RFP), the global gyrokinetic code Gene is modified to describe global tearing mode instability via a
T. Jitsuk, A. Di Siena, M.J. Pueschel, P.W. Terry, F. Widmer, E. Poli, J.S. Sarff   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Hot tearing behavior of AZ91D magnesium alloy

Journal of Magnesium and Alloys
Hot tearing is a serious destructive solidification defect of magnesium alloys and other casting metals. Quantitative and controllable measurements on the thermal and the mechanical behavior of an alloy during its solidification process are crucial for ...
Honggang Zhong, Zenghuang Lin, Qingyou Han, Jiangfeng Song, Meicheng Chen, Xiangru Chen, Lijuan Li, Qijie Zhai   +7 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source