Results 41 to 50 of about 1,047,530 (303)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Effect of sheared flows on classical and neoclassical tearing modes [PDF]
, 2005 Effect of sheared flows on classical and neoclassical tearing modes This article has been downloaded from IOPscience.
M. P. Bora +9 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Non-ideal MHD growth of current interchange tearing modes at plasma edge and response to externally-imposed flow [PDF]
, 2023 0000-0001-5668-6900Current interchange tearing modes (CITMs) have been proposed to explain an intermittent eruption of electric current toward a divertor at an edge region of a tokamak device.
Linjin Zheng +5 more
core +1 more source
Neoclassical tearing mode seeding by Alfvén eigenmode coupling in MAST-U
Nuclear FusionWe present evidence of tearing mode seeding by nonlinear three-wave coupling of Alfvén eigenmodes in a tokamak plasma. Here, a m,n = 2,1 magnetic island appears to be seeded in a MAST-U discharge by coupling of $n = 2$ and $n = 3$ Alfvén eigenmodes ...
Kitt Thomas +8 more
doaj +1 more source
Journal of Materials Research and Technology, 2022 A novel refill friction stir spot welding (RFSSW) technique employing large-sized tools is proposed. The microstructure and mechanical properties of joints produced with a large-sized welding tool and a conventional tool are compared.
Yangfan Zou +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source