Results 41 to 50 of about 164,024 (261)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Congenital Nasolacrimal Duct Obstruction (CNLDO): A Review

Diseases, 2018
Congenital nasolacrimal duct obstruction (CNLDO) is a common condition causing excessive tearing or mucoid discharge from the eyes, due to blockage of the nasolacrimal duct system.
Aldo Vagge, Lorenzo Ferro Desideri, Paolo Nucci, Massimiliano Serafino, Giuseppe Giannaccare, Andrea Lembo, Carlo Enrico Traverso   +6 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A bibliometric and visualization analysis of electrochemical biosensors for early diagnosis of eye diseases

Frontiers in Medicine
Electrochemical biosensors can provide an economical, accurate and rapid method for early screening of disease biomarkers in clinical medicine due to their high sensitivity, selectivity, portability, low cost and easy manufacturing, and multiplexing ...
Fushen Zhang, Weiye Xu, Zejun Deng, Jufang Huang   +3 more
doaj   +1 more source

Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review

Life, 2022
Parkinson disease (PD) is a progressive, neurodegenerative disease of the central nervous system. Visual disturbance is one of the most frequent nonmotor abnormalities referred to by patients suffering from PD at early stages. Furthermore, ocular surface
Matilde Buzzi, Giuseppe Giannaccare, Michela Cennamo, Federico Bernabei, Pierre-Raphael Rothschild, Aldo Vagge, Vincenzo Scorcia, Rita Mencucci   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Prolactin Inducible Protein, but Not Prolactin, Is Present in Human Tears, Is Involved in Tear Film Quality, and Influences Evaporative Dry Eye Disease

Frontiers in Medicine, 2022
PurposeDecreased production of the aqueous component of the tear film is an important cause of the development of dry eye disease (DED). Tear production is influenced by hormones and hormone-like factors.
Katharina Jüngert, Friedrich Paulsen, Christina Jacobi, Christina Jacobi, Jutta Horwath-Winter, Fabian Garreis   +5 more
doaj   +1 more source

Correlation between Tear Osmolarity and Tear Meniscus [PDF]

Optometry and Vision Science, 2014
ABSTRACT Purpose To examine the relationship between tear meniscus height (TMH) and subjective meniscus grading (subjective tear meniscus [TM]) with tear osmolarity. Methods Tear osmolarity measurements (using TearLab)
García Resúa, Carlos, Pena Verdeal, Hugo, Remeseiro, Beatriz, Giráldez Fernández, María Jesús, Yebra-Pimentel Vilar, Eva   +4 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Tears in Horace’s «Satires»

Griseldaonline, 2023
The article aims to study the tears within Horace’s Satires, or in other words, in a genre that has its identity gesture in the opposite laughter. Such an investigation, supported by the tools of the pragmatics of human communication and linguistic and ...
Giulia Beghini
doaj   +1 more source