Results 11 to 20 of about 68,976 (225)

Preparation and Bioevaluation of Novel ^99mTc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

Pharmaceuticals, 2021
To develop novel 99mTc-labeled single-photon emission computed tomography (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2-nitroimidazole derivative) was designed and synthesized.
Qing Ruan, Qianqian Gan, Xuran Zhang, Si’an Fang, Junbo Zhang   +4 more
doaj   +1 more source

The Shortage of Technetium-99m and Possible Solutions

, 2020
Following a major shortage of 99Mo in the 2009–2010 period, concern grew that the aging reactor production facilities needed to be replaced.
T. Ruth
semanticscholar   +1 more source

A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging

Applied Sciences, 2019
Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging applications. Its peculiar physical and chemical properties make it particularly suitable for medical imaging.
Alessandra Boschi, Licia Uccelli, Petra Martini   +2 more
doaj   +1 more source

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

Molecules, 2018
Scorpionate ligands have played a crucial role in the development of technetium chemistry and, recently, they have also fueled important advancements in the discovery of novel diagnostic imaging agents based on the γ-emitting radionuclide ...
Petra Martini, Micol Pasquali, Alessandra Boschi, Licia Uccelli, Melchiore Giganti, Adriano Duatti   +5 more
doaj   +1 more source

Characterization, optimization, and in vitro evaluation of Technetium-99m-labeled niosomes

International Journal of Nanomedicine, 2019
Background and purpose Niosomes are nonionic surfactant-based vesicles that exhibit certain unique features which make them favorable nanocarriers for sustained drug delivery in cancer therapy.
Leanne De Silva, J. Fu, T. Htar, Saravanan Muniyandy, A. Kasbollah, W. H. B. Wan Kamal, L. Chuah   +6 more
semanticscholar   +1 more source

The optimization method for synthesis of technetium-99m-luteolin as radiotracer in the development of cancer drugs from flavonoid

Journal of Advanced Pharmaceutical Technology & Research, 2020
The aim of this study is to find the optimum conditions of labeling luteolin flavonoid compounds with technetium-99m (99mTc) to meet the purity requirements stated in the United States Pharmacopeia. This compound is expected to be a potential radiotracer
Danni Ramdhani, Maula Eka Sriyani, S Fairuz Nabila   +2 more
doaj   +1 more source

Synthesis and Evaluation of ^99mTc-Labelled 2-Nitroimidazole Derivatives with Different Linkers for Tumour Hypoxia Imaging

Pharmaceuticals, 2023
When developing novel radiopharmaceuticals, a linker moiety between the chelator and targeting vector can have a crucial influence on adjusting the affinity of the tracer and its biodistribution in organisms.
Qing Ruan, Yitong Liu, Lihao Liao, Jinyu Hao, Yuhao Jiang, Jianyong Jiang, Junbo Zhang   +6 more
doaj   +1 more source

Comparison of the absorbed dose for 99m Tc-diethylenetriaminepentaacetic acid and 99m Tc-ethylenedicysteine radiopharmaceuticals using medical internal radiation dosimetry

Journal of Medical Signals and Sensors, 2015
The aim of this study was the investigation of absorbed dose to the kidneys, spleen, and liver during technetium-99 m ethylene dicysteine and technetium-99 m diethylenetriaminepentaacetic acid ( 99m Tc-EC and 99m Tc-DTPA) kidney scan.
Shokufeh Pirdamooie, Ahmad Shanei, Masoud Moslehi   +2 more
doaj   +1 more source

99m-Technetium galactosyl human serum albumin scanning to evaluate liver function after stereotactic body radiotherapy for hepatocellular carcinoma: A case report

Radiology Case Reports, 2019
The primary choice among treatment options for liver malignancies is surgery. However, if surgery cannot be performed, Stereotactic body radiotherapy (SBRT) may be effective.
Osamu Tanaka, MD, Kazutaka Miki, RT, Takuya Taniguchi, MP, Takao Kojima, MD, Akihiro Ohbora, MD, Chiyoko Makita, MD, Masayuki Matsuo, MD   +6 more
doaj   +1 more source

Reverse cardiac remodelling and dysfunction in A97S transthyretin cardiac amyloidosis after tafamidis treatment

ESC Heart Failure, 2022
Transthyretin cardiomyopathy (ATTR‐CM) is an under‐recognized cause of heart failure, but it has received increasing attention due to the availability of treatment options.
Yuan‐Kun (Aden) Wu, Cheng‐Hsuan Tsai, Mao‐Yuan Su, Chi‐Chao Chao, Mei‐Fang Cheng, Chia‐Tung Shun, Sung‐Tsang Hsieh, Yen‐Hung Lin   +7 more
doaj   +1 more source