Results 61 to 70 of about 98,425 (396)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans [PDF]

, 2009
International audienceParticulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. Recent studies investigated whether and to which extent inhaled ultrafine particles are able to translocate into the bloodstream in
Bois, Frédéric Y., Brochot, Céline, Hoet, Peter, Nemmar, Abderrahim, Pery, Alexandre R.R.   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Bioorganometallic Technetium and Rhenium Chemistry: Fundamentals for Applications

CHIMIA, 2020
Due to its long half-life of 2.111×105 y, technetium, i.e. 99Tc, offers the excellent opportunity of combining fundamental and ' classical ' organometallic or coordination chemistry with all methodologies of radiochemistry.
Roger Alberto, Henrik Braband, Qaisar Nadeem   +2 more
doaj   +1 more source

Reactions of technetium hexafluoride with nitric acid, nitrosyl fluoride, and nitryl fluoride [PDF]

, 1970
Stoichiometry of technetium hexafluoride reactions is studied. Magnetic properties and infrared spectra of reaction products are studied and compared with those of analogous complexes of the hexafluorides of tungsten, rhenium, and ...
Holloway, J. H., Selig, H.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Thionitrosyl Complexes of Rhenium and Technetium with PPh₃ and Chelating Ligands—Synthesis and Reactivity

Inorganics
In contrast to corresponding nitrosyl compounds, thionitrosyl complexes of rhenium and technetium are rare. Synthetic access to the thionitrosyl core is possible by two main approaches: (i) the treatment of corresponding nitrido complexes with S2Cl2 and (
Domenik Nowak, Adelheid Hagenbach, Till Erik Sawallisch, Ulrich Abram   +3 more
doaj   +1 more source

Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds [PDF]

Nanomedicine Journal
Objective(s): Scientists have been focused on finding access to the potential of different materials, incredibly natural substances. This work compared two categories of nanoscale materials based on carbon sources, including carbon quantum dots (C-QDs ...
Somayeh Marouzi, Shirin Sammak, Kayvan Sadri, Majid Darroudi   +3 more
doaj   +1 more source

The Periodic Table\u27s 150th Anniversary [PDF]

, 2019
Word play using the names of the ...
Francis, Darryl
core   +1 more source

Behavior of technetium in nuclear waste vitrification processes

Journal of Radioanalytical and Nuclear Chemistry, 2015
Nearly 100 tests were performed with prototypical melters and off-gas system components to investigate the extents to which technetium is incorporated into the glass melt, partitioned to the off-gas stream, and captured by the off-gas treatment system ...
I. Pegg
semanticscholar   +1 more source