Results 41 to 50 of about 16,428 (257)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Grip and manipulation forces are controlled independently in a coupled bimanual task

Journal of NeuroEngineering and Rehabilitation
Background Grasping and manipulating objects requires humans to adapt both grip and manipulation forces. When handling an object with both hands, the additional degrees of freedom introduce more levels to the redundancy of the object manipulation since ...
Clara Günter, Niklas Heimburger, David W. Franklin, Raz Leib   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structure of technical diagnostics integrated information systems

, 2014
Розглянуто структуру системи технічної діагностики інтегрованої інформаційної системи. Виділені основні режими контролю її елементів. Визначені складові та функції елементів динамічної експертної системи, що пропонується.
Kovalenko, Alexander, Kovalenko, Anna, Smirnov, Alexey, Коваленко, А. С., Коваленко, О. В., Смірнов, О. А.   +5 more
core   +1 more source

Generation of high-quality single-stranded DNA for full-length and truncated genome standards of recombinant adeno-associated viruses

Molecular Therapy: Methods & Clinical Development
The integrity of the single-stranded DNA (ssDNA) genome of recombinant adeno-associated viral vectors (rAAVs) for gene therapy applications is a critical quality attribute.
Julia Manz, Raphael Ruppert, Markus Haindl, Jürgen Hubbuch, Tobias Graf, Johannes Pschirer   +5 more
doaj   +1 more source

Application of logic 4-valued in the process of reasoning in diagnostic systems [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2016
The article presents application of logic 4-valuable in the process of reasoning in diagnostic systems. For this purpose, the structure of an intelligent diagnostic system (DIAG 2) is presented and defined. Its essential modules: measurement, calculation,
Stanisław Duer, Konrad Zajkowski, Radosław Duer   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Knowledge base of wind farm devices in the computer expert system [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2018
The article presents the problems of determining diagnostic information for the needs of testing the state of wind farm equipment. To this end, the essence of developing a functional and diagnostic model on the example of wind power plant equipment has ...
Radosław Duer, Paweł Wrzesień, Stanisław Duer, Dariusz Bernatowicz   +3 more
doaj   +1 more source

Diagnostics, Divergences and Perturbation Analysis [PDF]

, 1989
1 online resource (PDF, 24 pages)Geisser, Seymour. (1989). Diagnostics, Divergences and Perturbation Analysis.
Geisser, Seymour
core