Results 51 to 60 of about 16,428 (257)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Examination of informativeness of diagnoses expressed with multiple-valued logic [PDF]

open access: yesBiuletyn Wojskowej Akademii Technicznej, 2018
This paper presents the essence of an examination of informativeness in the diagnostic information outputs expressed with multiple-valued logic. The diagnostic test required for the examination was completed on wind turbine equipment.
Stanisław Duer   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Establishing Multi-Dimensional LC-MS Systems for Versatile Workflows to Analyze Therapeutic Antibodies at Different Molecular Levels in Routine Operations

open access: yesPharmaceuticals
Background/Objectives: Multi-dimensional liquid chromatography coupled with mass spectrometry (mD-LC-MS) has emerged as a powerful technique for the in-depth characterization of biopharmaceuticals by assessing chromatographically resolved product ...
Katrin Heinrich   +9 more
doaj   +1 more source

Improvements to the procedure for determination of the residual lifetime of railway vehicles

open access: yesЗбірник наукових праць Державного університету інфраструктури та технологій: серія "Транспортні системи і технології", 2023
Existing research concerning the extention of the service life of various types of railway vehicles and assessing its remaining lifetime has been reviewed and analyzed. It has been established that the vast majority of studies relate to the assessment of
A. Sulym   +4 more
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Adaptive Technology Application for Vibration-Based Diagnostics of Roller Bearings on Industrial Plants

open access: yesTransport and Telecommunication, 2014
Roller bearings are widely used in equipment of different applications; therefore, the issues related to the assessment of bearing technical state and localization of bearing faults are quite important and relevant.
Mironov Aleksey   +3 more
doaj   +1 more source

Technical diagnostics of electrical installations based on unmanned aerial vehicles

open access: yes, 2021
Метою кваліфікаційної роботи є зниження технологічних порушень у роботі повітряних ліній електропередавання з неізольованими проводами, що знаходяться тривалий час в експлуатації, на базі вдосконалення їх систем технічного діагностування.
Tokar, Ihor   +1 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Selection and study of methods for implementing a diagnostic model for compressor stations of the rocket and space complex [PDF]

open access: yesОмский научный вестник: Серия "Авиационно-ракетное и энергетическое машиностроение"
The article considers a compressed air system as an object of diagnosis, which is part of a complex of compressor equipment for the production, storage, and distribution of gases for spaceports providing launch vehicles.
A. V. Burakov   +2 more
doaj   +1 more source

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