Results 71 to 80 of about 606,110 (262)

Energy efficiency evaluation of construction projects using data envelopment analysis and Tobit regression

Scientific Reports
Energy efficiency (EE) in the construction sector is crucial for sustainable development, particularly in emerging economies like Pakistan, where the industry accounts for a large share of energy consumption and environmental degradation.
Muzaffar Iqbal, Junhai Ma, Zulqarnain Mushtaq, Naveed Ahmad, Muhammad Zain Yousaf, Bashar Tarawneh, Wajid Khan, Mukesh Pushkarna, Ievgen Zaitsev   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

DIRECT FREQUENCY CONVERTER WITH ARTIFICIAL AND NATURAL COMMUTATION FOR BRUSHLESS ASYNCHRONIZED MACHINES

Electrical engineering & Electromechanics, 2015
The comparative analysis of direct frequency converters with artificial and natural- switching term of the cyclical control algorithm is presented; the recommendations for their using in brushless asynchronized machines with three-phase winding are ...
А.М. Galynovskiy, E.А. Lenskaya, N.P. Melnik   +2 more
doaj  

Technical objects' ecological efficiency indicators control

Автоматизация технологических и бизнес-процессов, 2019
Traditional automatic control systems do not solve the task of limiting the harmful effects of technical objects on the environment. The problem is to increase the effectiveness of means of its protection against the harmful effects of industry. Relevant
S. A. Voinova
doaj   +1 more source

Technical Efficiency of Innovations in Poland from EU Perspective

Gospodarka Narodowa. The Polish Journal of Economics, 2019
This paper presents the results of an assessment of technical efficiency of innovations in European Union. Data Envelopment Analysis was used to investigate this subject.
Wojciech Nasierowski
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

DETERMINANTS OF TECHNICAL EFFICIENCY IN CROATIAN HOSPITALS

Ekonomska misao i praksa
This paper evaluates the technical efficiency of 26 Croatian general hospitals, clinical hospitals, and clinical hospital centres, and examines its determinants across the pre-pandemic (2015–2016) and pandemic (2021–2022) periods. Technical efficiency is defined as a hospital’s ability to maximise outputs from given inputs relative to the best ...
Simona Prijaković, Romario Marijanović, Mihaela Bronić   +2 more
openaire   +2 more sources