Results 81 to 90 of about 642,012 (263)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The weighted Russell measure of technical efficiency

European Journal of Operational Research, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
John Ruggiero, Stuart Bretschneider
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Features of Structural–Phase Changes and Tribological Behavior of Tool Steel After Vacuum and Plasma Electrolytic Nitriding

Journal of Manufacturing and Materials Processing
Nitriding is one of the technologies used to improve the performance properties of tool steels. In addition to traditional gas nitriding, technologies aimed at increasing the productivity and/or efficiency of processing have found application in industry.
Marina A. Volosova, Sergei A. Kusmanov, Tatiana L. Mukhacheva, Ivan V. Tambovskiy, Artem O. Komarov, Andrey E. Smirnov, Svetlana F. Katerzhina, Igor V. Suminov, Sergey N. Grigoriev   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Measuring efficiency of secondary healthcare providers in Slovenia

Open Medicine, 2017
The chief aim of this study was to analyze secondary healthcare providers' efficiency, focusing on the efficiency analysis of Slovene general hospitals.
Blatnik Patricia, Bojnec Štefan, Tušak Matej   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Economics of Potato Seed Production– an Analytical Study from Terai Zone of West Bengal

International Journal of Economic Plants, 2021
The study was conducted to analyze the economics of cultivation of potato seed in respect of technical efficiency and allocative efficiency in Terai zone of West Bengal, India based on primary data collected during September 2018 to March, 2019.
Nityananda Layek, Gobinda Mula
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Efficiency Level of Health Spending Governments: Evidence from North Maluku Indonesia

Jurnal Ekonomi dan Studi Pembangunan
This study aims to determine and analyze the level of technical efficiency, cost, technical systems and corrective steps that need to be taken by inefficient regions in 10 regencies/cities in North Maluku Province in 2016-2020.
Prince Charles Heston Runtunuwu, Mochamad Roland Perdana   +1 more
doaj   +1 more source