Results 51 to 60 of about 328,124 (261)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Applied Sciences, 2019 This article presents a performance evaluation of a flexible manufacturing system (FMS), in which the system and its components can have different performance levels ranging from perfect functioning to total failure.
Wenbin Zeng +8 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IEEE AccessData-driven methods have been shown to be suitable for the diagnosis and prognosis of the health of engineering systems. However, the training of data-driven methods usually requires a large amount of data, which is rarely available in industry.
Marcel Braig, Peter Zeiler
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
CrystalsDue to its good conductive properties, unalloyed (pure) aluminum, such as EN AW-1050A H24, finds new fields of application in electromobility. To optimize components, the cyclic material behavior must be understood and described precisely as a foundation
Tim Korschinsky +3 more
doaj +1 more source
Наука и техника, 2006 The paper presents main statements of the developed general scientific principles and experimental and analytical method for accelerated bench test of bearing structures and machine parts at a regular loading.
E. K. Pochtenny, P. P. Kapusta
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
IET Renewable Power GenerationThis study delves into the challenge of efficiently digitalising wind turbine maintenance data, traditionally hindered by non‐standardised formats necessitating manual, expert intervention. Highlighting the discrepancies in past reliability studies based
Julia Walgern +6 more
doaj +1 more source
Maintenance Optimization of Industrial Chimneys Exposed to Carbonation
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017 The paper is focused on the deterioration of industrial reinforced concrete chimneys caused by carbonation. It is considered that a chimney has to be repaired when more than 30% of its surface is affected by visible corrosion-induced cracks.
Mlčoch Jan +2 more
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