Results 71 to 80 of about 328,124 (261)
Transport and Telecommunication, 2016 The present paper deals with the vehicle’s traction electric drive, consisting of several various electric power sources. One of the main requirements for such systems are the safety and sustainable operations, achieved largely the implementation of an ...
Frenkel Ilia +3 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Human reliability in maintenance of technical systems
Vojnotehnički Glasnik, 1998 This paper presents one approach to define possible human errors and their contributing factors in maintenance of technical systems. Possible human errors in maintenance are estimated on automatic guns. The paper describes a possible way of estimation of
Slobodan Ilić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Quality Management and Reliability of Technical Systems
IOP Conference Series: Materials Science and Engineering, 2019 Ensuring the high quality and reliability of complex technical systems in the modern world remains the sharpest and most relevant topic. High dynamics of changes in technical products, such as automobiles, military equipment, marine vessels, electronic industry products, machine tools and equipment, dictates the conditions for revising methods and ...
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ANALYSIS OF TECHNICAL RELIABILITY OF INFORMATION SOURCES IMPACT FOR ITS RELIABILITY
The paper analyses the influence of real technical reliability of information sources on its reliability. A method of improving the reliability and security of information based on the majority principle of redundancy is proposed. With the majority decision-making method, it is very important to take into account the principle of ‘who is in favour ...
Dyachenko P. +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source