Results 81 to 90 of about 4,260,459 (301)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Study on Using Transfer Learning to Utilize Information From Similar Systems for Data-Driven Condition Diagnosis and Prognosis

IEEE Access
Prognostics and health management (PHM) is a field of study that aims to diagnose the health of engineering systems and predict their future degradation.
Marcel Braig, Peter Zeiler
doaj   +1 more source

The Lz-Transform Method for the Reliability and Fault Tolerance Assessment of Norilsk-Type Ship’s Diesel-Geared Traction Drives

Transport and Telecommunication, 2018
This paper focuses on a comparative analysis of the most important parameters of an icebreaker ship’s sustainable operations: the operational availability, power performance and power performance deficiency of the multi-state Multi-Power Source Traction ...
Frenkel Ilia, Bolvashenkov Igor, Khvatskin Lev, Lisnianski Anatoly   +3 more
doaj   +1 more source

Analysis of Partial Factors for New EN 1990 Basis of Design

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017
Presently the new generation of Eurocodes is under development. It is expected that the basis of structural design given in current EN 1990 will be considerably revised including the format for load combinations in the Ultimate Limit States and new ...
Marková Jana
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Electricity Access in Sub-Saharan Africa: Uptake, Reliability, and Complementary Factors for Economic Impact

, 2019
Access to reliable electricity is a prerequisite for the economic transformation of economies in Sub-Saharan Africa (SSA), especially in a digital age.
Moussa P. Blimpo, M. Cosgrove-Davies
semanticscholar   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Performance Availability Assessment of Combined Multi Power Source Traction Drive Considering Real Operational Conditions

Transport and Telecommunication, 2016
The present paper deals with the vehicle’s traction electric drive, consisting of several various electric power sources. One of the main requirements for such systems are the safety and sustainable operations, achieved largely the implementation of an ...
Frenkel Ilia, Bolvashenkov Igor, Herzog Hans-Georg, Khvatskin Lev   +3 more
doaj   +1 more source