Results 81 to 90 of about 4,214,349 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Study on Using Transfer Learning to Utilize Information From Similar Systems for Data-Driven Condition Diagnosis and Prognosis

IEEE Access
Prognostics and health management (PHM) is a field of study that aims to diagnose the health of engineering systems and predict their future degradation.
Marcel Braig, Peter Zeiler
doaj   +1 more source

The Lz-Transform Method for the Reliability and Fault Tolerance Assessment of Norilsk-Type Ship’s Diesel-Geared Traction Drives

Transport and Telecommunication, 2018
This paper focuses on a comparative analysis of the most important parameters of an icebreaker ship’s sustainable operations: the operational availability, power performance and power performance deficiency of the multi-state Multi-Power Source Traction ...
Frenkel Ilia, Bolvashenkov Igor, Khvatskin Lev, Lisnianski Anatoly   +3 more
doaj   +1 more source

Analysis of Partial Factors for New EN 1990 Basis of Design

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2017
Presently the new generation of Eurocodes is under development. It is expected that the basis of structural design given in current EN 1990 will be considerably revised including the format for load combinations in the Ultimate Limit States and new ...
Marková Jana
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Electricity Access in Sub-Saharan Africa: Uptake, Reliability, and Complementary Factors for Economic Impact

, 2019
Access to reliable electricity is a prerequisite for the economic transformation of economies in Sub-Saharan Africa (SSA), especially in a digital age.
Moussa P. Blimpo, M. Cosgrove-Davies
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Performance Availability Assessment of Combined Multi Power Source Traction Drive Considering Real Operational Conditions

Transport and Telecommunication, 2016
The present paper deals with the vehicle’s traction electric drive, consisting of several various electric power sources. One of the main requirements for such systems are the safety and sustainable operations, achieved largely the implementation of an ...
Frenkel Ilia, Bolvashenkov Igor, Herzog Hans-Georg, Khvatskin Lev   +3 more
doaj   +1 more source