Results 91 to 100 of about 1,034,675 (254)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Dejan Lovrinčević, PhD in Technical Sciences

open access: yesKartografija i Geoinformacije, 2018
Dejan Lovrinčević defended his doctoral thesis A New Method of Automatic Sounding Selection on Nautical Charts on 5 October 2018. The commission for the defence of the doctoral thesis comprised Prof. Dr. Stanislav Frangeš, Assist. Prof. Dr. Robert Župan,
Miljenko Lapaine
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Mario Mađer PhD in Technical Sciences

open access: yesKartografija i Geoinformacije, 2012
Mario Mađer defended his doctoral thesis Model for Linking Cadastre with Related Registers at the Faculty of Geodesy, University of Zagreb on November 5, 2012. Prof. Dr. Siniša Mastelić Ivić, Prof. Dr. Miodrag Roić (mentor) and Assist. Prof.
Miodrag Roić
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Branka Barišić MSc in Technical Sciences

open access: yesKartografija i Geoinformacije, 2012
Branka Barišić defended her Master’s thesis Coastal Spatial Data Infrastructure at the Faculty of Geodesy of the University of Zagreb on July 13, 2012. Her mentor was Prof. Dr. Vlado Cetl. The examining and defence committee consisted of Prof. Dr. Siniša
Vlado Cetl
doaj  

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Sanja Zekušić, MSc in Technical Sciences

open access: yesKartografija i Geoinformacije, 2011
On 19 December 2011, Sanja Zekušić defended her Master’s thesis Official Spatial Data as the Basis for Management in Agriculture at the Faculty of Geodesy of the University of Zagreb. Her supervisor was Prof. Dr. Miljenko Lapaine. The Examining Committee
Miljenko Lapaine
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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