Results 91 to 100 of about 15,653,086 (211)
PROPERTIES OF GENERALIZED BENDING
, 1971 QC 351 A7 no. 64Generalized bending is a one -parameter family of changes to two curvatures and related thicknesses of a previously defined optical system consisting of spherical and plane refracting surfaces.
Darnauer, James H.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
BAND-UNLIMITED RECONSTRUCTION OF OPTICAL OBJECTS AND SPECTRAL SOURCES
, 1967 QC 351 A7 no. 18This paper derives a method for digitally reconstructing any two-dimensional, partially coherent, polychromatic object from experimental knowledge of the image and point spread function.
Frieden, B. Roy
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1969 QC 351 A7 no. 46Simple inverse filtering of each spectral component of a color picture can lead to serious misregistration of the restorations. This is a consequence of the nonlinearity of the photographic process, which distorts edges of objects in an ...
Frieden, B. Roy
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A NEW RETINAL MODEL AND ITS APPLICATION TO THE COMPUTER ANALYSIS OF AERIAL PHOTOGRAPHS
, 1971 QC 351 A7 no. 70In order to find a new and more economical method for the computer detection of object outlines in aerial photographs, the human visual system is considered. This leads to the concept of the human retina as a matrix of light receptors and
Sadowski, Alexander M.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 1967 QC 351 A7 no. 14Lens designers who use automatic programs and large computers are no longer considered to be pioneers but are now an integral part of the world's rapidly-expanding optical industry. Various techniques of automatic correction, though still
Wilkerson, Gary W., Lytle, John D.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source