Results 81 to 90 of about 15,653,086 (211)
DESIGN HISTORY AND SPECIFICATIONS FOR THE MARINER '69 HIGH-RESOLUTION TELESCOPE
, 1970 QC 351 A7 no. 51This report presents the author's basic findings on various optical systems that he studied and /or designed at the Jet Propulsion Laboratory, Pasadena, California, for the high -resolution telescope of NASA's Mariner '69 and '71 ...
Wilkerson, Gary W.
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A TWO CHANNEL PHOTOGRAPHIC PLATE GUIDING CONTROL SYSTEM
, 1967 QC 351 A7 no. 20The control system described in this thesis was designed to automatically guide the position of photographic plates during long exposures of astronomical objects.
Reed, Michael A.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A COMPARISON OF THE SQUARE WAVE RESPONSE OF THREE MICROSCOPES COMMONLY USED IN PHOTOINTERPRETATION
, 1970 QC 351 A7 no. 53The optical performance of three stereomicroscopes commonly used for photo - interpretation is described in terms of magnification, field of view, and square wave response (SqWR).
Hooker, R. Brian
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 1968 QC 351 A7 no. 32A random perturbation in the wavefront transmitted through an optical system results in diffraction effects in the image which are describable in terms of the statistical measures of the wavefront perturbations, whereas the geometrical ...
Shack, R. V.
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
INVESTIGATION OF TECHNIQUES FOR FABRICATING PLASTIC OPTICAL COMPONENTS
, 1972 QC 351 A7 no. 77Because of their light weight and low cost, transparent plastics would seem to be good materials for optical components. This thesis deals primarily with the feasibility of producing large ( >4 -in.
Blecher, Stephen
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source