Results 101 to 110 of about 1,197,354 (304)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
PROBLEMS IN NULL CORRECTOR DESIGN
, 1969 QC 351 A7 no. 39Optical systems known as "null correctors" are often required to test certain aspheric optical surfaces. This report classifies these systems on the basis of their first -order geometry and analyzes the merits of each type.
Lytle, John D.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
EARTH-ORBITAL ELECTRO-OPTICAL MULTIBAND CAMERA
, 1970 QC 351 A7 no. 62Multiband photography has been used for several years as a tool for aerial reconnaissance. Recent experiments indicate a potential value in earth resources studies, particularly those utilizing an electro-optical image sensor. This report
Baker, L. Ralph
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
EARTH ORBITAL ELECTRO-OPTICAL MULTIBAND CAMERA: IMAGE SENSOR REPORT
, 1970 QC 351 A7 no. 52Multiband photography has been employed for several years as a tool for aerial reconnaissance. Recent experiments indicate a potential value in earth resources studies, particularly those utilizing an electro-optical image sensor.
Baker, L. Ralph, Slater, Philip N.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
APPLICATION OF ASPHERICS FOR WEIGHT REDUCTION IN SELECTED CATADIOPTRIC LENSES
, 1971 QC 351 A7 no. 69The history of modern wide -field, high-speed catadioptric lenses is reviewed. One system comprising only spherical curves and representative of the current art for low-light-level systems is evaluated and used as a baseline design in a ...
Buchroeder, Richard A.
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
SYNERGETICS IN TECHNICAL AND ARTISTIC SCIENCES
The American Journal of Engineering and TechnologyThis article will rediscover the participation of synergistic competence in the Integrative teaching of technical and art disciplines, the importance of pedagogical synergetics and approaches.
openaire +1 more source