Results 41 to 50 of about 379,673 (256)

Are the Immunohistochemistry-Based Biomarkers Helpful for Predicting Prognosis in Patients with Surgically Resected Cholangiocarcinoma?

Gut and Liver, 2023
Background/Aims: Bilateral endoscopic drainage with self-expanding metallic stent (SEMS) can be used to effectively manage hilar malignant biliary obstruction. However, the benefits of using a trisegment drainage method remain unknown.
Dong Uk Kim
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Primary Results of the SALAMANDER Registry: A Multicenter Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The balance between thromboembolic complications and bleeding risk in anticoagulated patients with atrial fibrillation remains challenging, with left atrial appendage occlusion (LAAO) representing a potential alternative.
Wojciech Wańha, Łukasz Kuźma, Mariusz Kowalewski, Sylwia Iwańczyk, Joanna Grygier, Jan Jeske, Marco Frazzetto, Radosław Litwinowicz, Marian Burysz, Ewa Gaszewska‐Żurek, Claudio Sanfilippo, Tomasz Bochenek, Michał Lelek, Krystian Wita, Zenon Huczek, Agnieszka Kapłon‐Cieślicka, Tomasz Mazurek, Piotr Scisło, Jerzy Sacha, Krzysztof Struniawski, Brunon Tomasiewicz, Facehauwe Mezque, Wiktor Kuliczkowski, Krzysztof Bartuś, Sławomir Dobrzycki, Michał Święczkowski, Anna Kurasz, Paweł Kralisz, Dawid Miśkowiec, Jarosław D. Kasprzak, Marta Chamera, Maksymilian Mielczarek, Piotr Drewla, Rafał Gałąska, Fabrizio Ugo, Marco Franzino, Bernardo Cortese, Filippo L. Gurgoglione, Luigi Vignali, Giorgio Benatti, Federico Barocelli, Piotr Waciński, Piotr Niezgoda, Adam Sukiennik, Jacek Kubica, Mario Iannacone, Klaudia Kowalska, Łukasz Lewicki, Carmelo Grasso, Davide Capodanno, Fabrizio D'Ascenzo, Ovidio de Filippo, Francesco Bruno, Radosław Gocoł, Zbigniew Kalarus, Piotr Suwalski, Marek Grygier, Grzegorz Smolka, Gregory Y.H. Lip, Wojciech Wojakowski   +59 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Therapeutic vaccines for chronic diseases: successes and technical challenges [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
Abstract Chronic, non-communicable diseases are the major cause of death and disability worldwide and have replaced infectious diseases as the major burden of society in large parts of the world. Despite the complexity of chronic diseases, relatively few predisposing risk factors have been identified by the World Health Organization ...
Bachmann, M, Jennings, G
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Technical Complications and Marginal Bone Loss Depending on the Crown Material of Dental Implants in the Posterior Region: A 3-Year Randomized Clinical Study

Dentistry Journal
Background/Objectives: This single-center, randomized controlled clinical trial evaluated the impact of two crown materials—lithium disilicate (LS2) and a polymer-infiltrated hybrid ceramic (HC)—on the marginal bone loss (MBL) and the technical ...
Sigmar Schnutenhaus, Marla Weinmann, Max Römer, Ralph G. Luthardt   +3 more
doaj   +1 more source

Infrapopliteal Percutan Transluminal Angioplasty of Patients with TASC D Group Diabetic Foot Lesions According to the Transatlantic Inter-Society Consensus II

Haseki Tıp Bülteni, 2017
Aim: We aimed to evaluate the effectiveness of percutaneous transluminal angioplasty (PTA) in limb salvage in patients with diabetic foot disease and critical limb ischemia according to the Trans-Atlantic Inter-Society Consensus II (TASC) classification ...
Mehmet Burak Çildağ, Ömer Faruk Kutsi Köseoğlu, Mustafa Bülent Ertuğrul   +2 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source