Results 41 to 50 of about 6,695,348 (295)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Adenocarcinoma: A Scoping Review with Meta-Analysis

Diagnostics
Background: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has recently been proposed as an alternative treatment option for patients with unresectable pancreatic adenocarcinoma (uPDAC) or metastatic pancreatic adenocarcinoma (mPDAC ...
Cristian George Tieranu, Daniel Vasile Balaban, Daniela Tabacelia, Artsiom Klimko, Cristian Gheorghe, Stephen P. Pereira, Mariana Jinga, Adrian Saftoiu   +7 more
doaj   +1 more source

Conception rates after fluoroscopy-guided fallopian tubal cannulation: an alternative to fertilization for patients with tubal occlusion

Therapeutic Advances in Reproductive Health, 2020
Objective: Previous studies show good technical success rates for fallopian tube recanalization. Scarce literature exists regarding advance techniques currently used by interventional radiologists during fallopian tube recanalization procedures.
Jeffrey W. Wang, Gabriella M. Rustia, Mary Wood-Molo, Jordan Tasse, David Tabriz, Ulku C. Turba, Bulent Arslan, Sreekumar Madassery   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Stressing Success: Examining Hmong Student Success in Career and Technical Education [PDF]

Hmong Studies Journal, 2014
This study examines factors affecting the academic performance of Hmong students at Chippewa Valley Technical College in Eau Claire, WI. Factors specifically analyzed for their impact upon student success are socioeconomic status, family support, the use
Carmen M. Iannarelli
doaj  

Preparation of Fox Valley Technical College faculty for multicultural education [PDF]

, 2000
Includes bibliographical references.The purpose of this study was to determine the level of preparedness of Fox Valley Technical College faculty for multicultural education.
Grimm, Gretchen K.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effectiveness of spherical tip noncompliant balloon for stent postdilatation: the REPIC02-RECONQUISTHA study

REC: Interventional Cardiology (English Ed.), 2022
Introduction and objectives: Noncompliant balloon postdilatation of coronary stents improves clinical results. Regular noncompliant balloons (RegNC) have less crossability and a tapered-tip that can complicate successful stent postdilatation.
José Antonio Linares Vicente, Koldo García San Román, Fernando Lozano Ruiz-Póveda, Gabriela Veiga Fernández, Antonio Gómez Menchero, Gerardo Moreno Terribas, Gema Miñana Escrivà, Joaquín Sánchez Gila, Carlos Arellano Serrano, José Ramón Rumoroso Cuevas, Ginés Martín Cáceres, Pablo Bazal Chacón, Pedro Martín Lorenzo, Fernando Rebollal Leal, José Moreu Burgos, Armando Pérez de Prado   +15 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source