Results 91 to 100 of about 6,654,042 (264)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Technique, technologie

, 2020
Le Groupement de recherche 2092 Techniques et production dans l’histoire (GDR TPH) propose deux ateliers-concept sur le thème Technique, technologie. Le premier s'est déroulé le 30 novembre 2020.
Géraldine Barron
core  

Apport du financement du système de santé dans le domaine des équipements biomédicaux aux structures de santé de la ville de KOLWEZI. Cas de l’Hôpital de Mwangeji et de Centre de santé de Dilala. Kolwezi (Lualaba), République démocratique du Congo

Revue Congolaise des Sciences et Technologies
Les équipements biomédicaux jouent un rôle crucial dans la qualité des soins de santé. Toutefois, leur disponibilité et leur fonctionnalité dépendent fortement des mécanismes de financement du système de santé.
Fidèle Kambaj Mutombu, Alexis Lukamba Tohemo, Jean René Kwete Manga, André Tshibad Yirung, Gabin Kaumb Kalau, Aide-Stéphane Imani Amisi, José Kibembe Mubaya, Jean-Pierre Ilengi Mbula Basila   +7 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Research on the Compound Drought and High-Temperature Events During the Flowering Period of Summer Maize in the Huang-Huai-Hai Region of China

Advances in Meteorology
With global warming, the frequent occurrence of extreme weather events, especially compound extreme disaster events, poses a serious threat to China’s food security.
Yanling Guo, Ruirui Si, Dongyao Shang
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

THE IMPORTANCE OF OPTIMIZATION OF LATTICE STRUCTURES FOR BIOMEDICAL APPLICATIONS

Nonconventional Technologies Review, 2019
The paper describes the importance of optimization of lattice structures intended to be used in medical applications. Additive manufacturing process gains an important place in the medical industry due to the ability to obtain complex geometries ...
Luciana Laura Shamieh-Dinca, Nicoleta Mirela Popa, Nichita Larisa Milodin, Doina Gheorghiu, Stanca Comsa   +4 more
doaj