Results 101 to 110 of about 12,947,219 (281)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Wide Field Multicolor CCD Photometry of the Open Cluster NGC752

Open Astronomy, 2010
The results of CCD photometry in the seven-color Vilnius system of 3058 stars down to V ~ 18.0 mag in a 1.5 square degree field around the cluster NGC 752 are presented.
Zdanavičius J., Bartašiutė S., Zdanavičius K.   +2 more
doaj   +1 more source

Particle-Based Mesoscale Hydrodynamic Techniques

, 2006
Dissipative particle dynamics (DPD) and multi-particle collision (MPC) dynamics are powerful tools to study mesoscale hydrodynamic phenomena accompanied by thermal fluctuations.
Allen M. P., Bird G. A., Bonet Avalos J., Español P., G Gompper, H Noguchi, Hoogerbrugge P. J., Ihle T., Lowe C. P., N Kikuchi, Peters E. A. J. F., Succi S.   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Análisis de las acciones técnicas de los judokas cadetes participantes en el campeonato de España. (Analysis of technical actions of the judoist cadets participating in the judo championship of Spain.) [PDF]

Revista Internacional de Ciencias del Deporte, 2009
ResumenEl entrenamiento del judoka dada su amplia estructura técnica, su dimensión táctica, su estructuración por categorías de peso y la incertidumbre creada por el adversario, muestra diversos y complejos aspectos a considerar, que deben ser analizados
Vicente Carratalá Deval, José Manuel García García, Luis Fernándes Monteiro   +2 more
doaj  

A Statistical Study of the Si IV Resonance Line Parameters in 19 Be Stars

Open Astronomy, 2011
Using the GR model, we analyze the ultraviolet Si IV resonance lines in the spectra of 19 Be stars of different spectral subtypes, in order to detect the presence of absorption components and to analyze their characteristics.
Antoniou A., Danezis E., Lyratzi E., Stathopoulos D., Dimitrijević M. S.   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Overlapping Open Clusters NGC 1750 and NGC 1758 behind the Taurus Dark Clouds. II. CCD Photometry in the Vilnius System

Open Astronomy, 2003
Seven-color photometry in the Vilnius system has been obtained for 420 stars down to V = 16 mag in the area containing the overlapping open clusters NGC 1750 and NGC 1758 in Taurus.
Straižys V., Kazlauskas A., Černiauskas A., Boyle R. P., Vrba F. J., Philip A. G. Davis, Laugalys V., Černis K., Smriglio F.   +8 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source