Results 41 to 50 of about 13,860,352 (334)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Detection and Quantification of Stagonosporopsis cucurbitacearum in Seeds of Cucurbita maxima Using Droplet Digital Polymerase Chain Reaction

open access: yesFrontiers in Microbiology, 2022
Stagonosporopsis cucurbitacearum is an important seedborne pathogen of squash (Cucurbita maxima). The aim of our work was to develop a rapid and sensitive diagnostic tool for detection and quantification of S.
Sergio Murolo   +6 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Strategies for socialization in children with autism spectrum disorder at home and in the classroom

open access: yesRevista Metropolitana de Ciencias Aplicadas
This essay focuses on describing and explaining how socialization was achieved in elementary school students with TEA, it is known is a disorder that causes alterations in language, communication, social interaction and thought forms, so the ...
Oscar José Martín-Pinto
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

open access: yesFEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki   +4 more
wiley   +1 more source

Partial Matrix Techniques. [PDF]

open access: yes, 1979
Partial matrix techniques are those in which gravity models are fitted to a partially observed matrix of trips and journey costs, and used to infer the trips in the unobserved cells.
Kirby, H.R.
core  

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Standard operating procedure: use in nursing care in hospital services Procedimiento operacional estándar: utilización en la asistencia de enfermería en servicios hospitalarios Procedimento operacional padrão: utilização na assistência de enfermagem em serviços hospitalares

open access: yesRevista Latino-Americana de Enfermagem, 2008
This is a descriptive and quantitative study, carried out in three hospitals in the Northwest of São Paulo, Brazil. It aimed to verify the existence and use of Standard Operating Procedures (SOP) by nursing teams.
Giselle Patrícia Guerrero   +2 more
doaj   +1 more source

RADOME ANALYSIS TECHNIQUES [PDF]

open access: yes, 2012
Radar Dome, or usually called Radome, is usually placed over the antenna as an antenna protector from any physical thing that can break it. Ideally, radome does not degrade antenna performance.
Christiyono, Yuli   +2 more
core  

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