Results 91 to 100 of about 191,750 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all animal species as preservative and silage additive, for pets and other non food‐producing animals (non‐food fur animals) as acidity regulator and for pets as flavouring

EFSA Journal, 2011
The additive (SBS) consists of sodium bisulphate without carrier materials. The applicants are seeking authorisation for SBS as a silage additive and for use as feed preservative for all animal species, as acidity regulator for pets and other non food ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Safety and efficacy of montmorillonite‐illite (FIMIX 1g557) for all animal species

EFSA Journal, 2020
Following a request from European Commission, the Panel on Additives and Products or Substances used in animal Feed (FEEDAP) was asked to deliver a scientific opinion on the modification of the terms of authorisation of montmorillonite‐illite (FIMIX ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Kos Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Rosella Brozzi, Jaume Galobart, Lucilla Gregoretti, Gloria López‐Gálvez, Maria‐Vittoria Vettori, Konstantinos Sofianidis, Matteo Lorenzo Innocenti   +24 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science
Piezoelectric biomaterials convert mechanical energy into electrical charges, making them promising candidates for bone tissue engineering by restoring and modulating the electrophysiological microenvironment.
Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo   +7 more
doaj   +1 more source

Open-source digital technologies for low-cost monitoring of historical constructions [PDF]

, 2017
This paper shows new possibilities of using novel, open-source, low-cost platforms for the structural health monitoring of heritage structures. The objective of the study is to present an assessment of increasingly available open-source digital modeling ...
Basto, Camilo, Chacón Flores, Rolando Antonio, Pelà, Luca   +2 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of Lactiplantibacillus plantarum NCIMB 41028 for all animal species (Genus Breeding Ltd.)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Lactiplantibacillus plantarum NCIMB 41028 as a technological additive to improve ensiling of fresh plant material. The additive
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Natalia Alija‐Novo, Montserrat Anguita, Nicole Bozzi Cionci, Matteo L. Innocenti, Fabiola Pizzo, Jordi Tarrés‐Call, Piera Valeri, Yolanda García‐Cazorla   +24 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source