Results 161 to 170 of about 4,038,530 (346)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
, 1970 Different types of food additives have been discussed. I have discussed the role of food additives to preserve nutritional values and to maintain desired consistency of the product.
Narendra Kumar Chaudhary
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Antioxidant Food Additives – Applications and Side Effects [PDF]
, 2017 Antioxidant food additives are added in small amounts to food stuff improve its durability by preventing food from deterioration due to oxidation. There are two main oxidation processes of foodstuff: (I) the enzymatic oxidation of fruits, vegetables ...
Silva, M., Lidon, F.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A Study of Metal-Cement Composites with Additives
The application of small-sized metal fillers (SMF) provides a combination of high bulk density, increased durability and ferromagnetic properties of composite materials on the cement basis.
Tatarinovs, Aleksejs +3 more
core
In-cylinder fuel and lubricant effects on gasoline engine friction [PDF]
, 2007 The purpose of the research reported in this thesis was to investigate the viability and quantify the potential gains of improving fuel economy of the gasoline engine through strategic application of additives.
Smith, Oiver Mark Edward +1 more
core
EFSA JournalFollowing a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of Levilactobacillus brevis DSM 21982 as a technological feed additive, silage additive, for all animal ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +24 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source