Results 111 to 120 of about 114,747 (258)

Structural and Technological Characterization of Tropical Smallholder Farms of Dual-Purpose Cattle in Mexico. [PDF]

open access: yesAnimals (Basel), 2020
Rangel J   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Comparative Technological Characterization of Clones of Variety Dimyat

open access: yesРастениевъдни науки, 2013
A comparative investigation of the technological characterization of clones and population of the cultivar Dimyat has been carried out. It has been found that the selected clones differ in the values of the indices of the mechanical and chemical ...
Iliyan Simeonov, Venelin Roychev
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A proposal for measuring the innovation performance: an application in spanish innovative firms

open access: yesManagement Letters/Cuadernos de Gestión, 2013
This paper supplies a measure of the degree of firm’s innovation performance. This indicator summarizes the impact of technological innovation activities on products, processes and sustainability of the firms. The data set used in this study was drawn up
María A. Quintás   +2 more
doaj  

Sensory profile and technological characterization of boneless dry-cured ham with lactulose added as a prebiotic. [PDF]

open access: yesAsian-Australas J Anim Sci, 2020
Gomes HB   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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