Results 121 to 130 of about 7,793,316 (286)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Endogenous Acceleration of Technological Change [PDF]
Our study shows that the technological development of a firm can be subject to an endogenous acceleration mechanism. The more advanced a firm is in using a particular set of technologies, the more likely will it adopt additional, related technologies ...
Philipp Köllinger, Christian Schade
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Technological characterization of gold jewellery from the Sogdian tomb of Shi Jun (d. 579 CE) in Xi'an, Shaanxi Province. [PDF]
Sci Rep, 2020 Tan P, Yang J, Liu Y, Zheng Y, Yang J.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Technological Change and Immigration [PDF]
We develop a simple model where two technologies are available to produce the same good, and we study under what conditions both will be used. We use the model to analyze the consequences of the simultaneous use of two different technologies for the ...
Francesc Dilme
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Bulletin of Texas Technological College Vol. 23 No. 2. [PDF]
, 1944 The PDF for the February, 1947, Graduate Studies course catalog at Texas Technological College is 31 pages ...
Texas Technological College.
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Sensory profile and technological characterization of boneless dry-cured ham with lactulose added as a prebiotic. [PDF]
Asian-Australas J Anim Sci, 2020 Gomes HB +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Ownership and Technological Capabilities in Brazil [PDF]
Over the last fifty years, foreign-owned firms have played an important role in developing the Brazilian industry. The focus of debate on the impacts of these firms upon technical change in Brazil has been on the use of technology.
Ionara Costa
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