Results 41 to 50 of about 40,350 (266)
Perspectives of Global Digital Governance for Space Exploration [PDF]
Advanced Space LawThe article reveals the latest perspectives of global digital governance for space exploration. Approaches to the formation of a general concept of global digital governance, which is focused on ensuring security, stability and inclusiveness in the ...
Diana Levchenko
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Developing the new productive forces by giving full play to advantages of supersize market: theoretical mechanism and practical path [PDF]
China Political EconomyPurposeChina has established a supersized market as a cornerstone of its long-term development strategy. To accelerate the cultivation of new quality productive forces (NQPFs) driven by innovation and digital transformation, it is essential to fully ...
Lijun Jia, Yaozheng Li, Xiaoxuan Shao
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Too many bits: tackling the waste epidemic in digital medicine
npj Digital MedicineAs digital medicine expands, the growing volume of unused (or underutilized) data are creating a hidden epidemic of technological waste. For example, the concept of a digital twin has gained rapid traction.
Conor Wall +5 more
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Taking value conflicts seriously: Technological pluralism as an approach to hydrogen governance
Energy Strategy ReviewsWe propose technological pluralism as a governance framework for navigating value conflicts arising from technological change within the energy system. The transition to clean hydrogen serves as a case in point as it gives rise to multiple (and complex ...
Eugen Octav Popa, Anna Melnyk
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Technological foundations of electronic governance
Proceedings of the 1st international conference on Theory and practice of electronic governance, 2007 This paper explores the relevance and opportunities for the application of mature Formal Techniques - techniques based on mathematical theories and supported by industry-ready tools and methods - to build technical solutions for Electronic Governance. The paper proceeds in four steps: (1) establishes the basic need for Formal Techniques in Electronic ...
Jim Davies +3 more
openaire +4 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Governance of Personal Information Security in the Iteration of Generative AI: From the Perspective of the Technological Evolution of Large Models [PDF]
Nongye tushu qingbao xuebao[Purpose/Significance] The rapid advancement of generative artificial intelligence (AI) is driving societal digital transformation, yet it simultaneously poses unprecedented systemic risks to personal information security due to the large-scale ...
AN Lin
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