Results 51 to 60 of about 526,015 (308)
Embracing the political in technology and transition studies: a response to Philip Vergragt and Bram Bos [PDF]
, 2013 This article is a short reaction to the comments of Vergragt (Found Sci, 2012) and Bos (Found Sci, 2012) on my article “Sustainability transition and the nature of technology” (Paredis in Found Sci 16(2–3):195–225, Paredis 2011).
Paredis, Erik
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Taking value conflicts seriously: Technological pluralism as an approach to hydrogen governance
Energy Strategy ReviewsWe propose technological pluralism as a governance framework for navigating value conflicts arising from technological change within the energy system. The transition to clean hydrogen serves as a case in point as it gives rise to multiple (and complex ...
Eugen Octav Popa, Anna Melnyk
doaj +1 more source
Industrial districts as organizational environments: resources, networks and structures [PDF]
, 2006 The paper combines economic and sociological perspectives on organizations in order to gain a better understanding of the forces shaping the structures of industrial districts (IDs) and the organizations of which they are constituted.
Popp, A., Toms, S., Wilson, J.
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Corporate governance systems in Europe : differences and tendencies of convergence ; Crafoord lecture [PDF]
, 1996 The corporate governance systems in Europe differ markedly. Economists tend to use stylized models and distinguish between the Anglo-American, the German and the Latinist model.1 In this view, for instance, the Austrian, Dutch, German, and Swiss systems ...
Baums, Theodor
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
MISSIONS FOR EU INNOVATION POLICY WHY THE RIGHT SET-UP MATTERS. Bertelsmann Stiftung Policy Paper N0. 224 29 May 2018 [PDF]
, 2019 The proposed introduction of research & innovation (R&I) missions in Horizon Europe, the next EU research programme, seems to be the most significant and ambitious change on previous programmes, especially given its implications for the governance of ...
Ständer, Philipp
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Too many bits: tackling the waste epidemic in digital medicine
npj Digital MedicineAs digital medicine expands, the growing volume of unused (or underutilized) data are creating a hidden epidemic of technological waste. For example, the concept of a digital twin has gained rapid traction.
Conor Wall +5 more
doaj +1 more source