Results 41 to 50 of about 679,114 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Framework for Market State Prediction with Ontological Asset Selection: A Multimodal Approach
Applied SciencesIn this study, we introduce a detailed framework for predicting market conditions and selecting stocks by integrating machine learning techniques with ontological financial analysis.
Igor Felipe Carboni Battazza +2 more
doaj +1 more source
Technological innovations and dynamics in economic theory
Ученые записки Российской академии предпринимательства, 2023 The use of different technologies gives a completely different technological chain in the form of technologicalinnovations.
S. S. Repin
doaj +1 more source
Journal of Global Information Management, 2018 The Mobile Internet Information Technology (MIIT) has been widely accepted as one of the most promising technologies in the next decades, having various applications and different value positions. However, few published studies explore and examine the effects of MIIT on community management.
Su, Wan +4 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The interplay between innovation adoption and pricing competitiveness in Sub-Saharan Africa
International Journal of Innovation StudiesThe objective of this work is to evaluate the effects of adopting technological innovation, non-technological innovation, and their complementarity on price competitiveness.
André Dumas Tsambou +3 more
doaj +1 more source
Can Technology Help Promote Equality of Educational Opportunities?
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2016 This chapter assesses the potential for several prominent technological innovations to promote equality of educational opportunities. We review the history of technological innovations in education and describe several prominent innovations, including ...
Brian Jacob +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The first look: a biometric analysis of emotion recognition using key facial features
Frontiers in Computer ScienceIntroductionFacial expressions play a crucial role in human emotion recognition and social interaction. Prior research has highlighted the significance of the eyes and mouth in identifying emotions; however, limited studies have validated these claims ...
Ana M. S. Gonzalez-Acosta +9 more
doaj +1 more source