Results 51 to 60 of about 81,391 (264)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The first look: a biometric analysis of emotion recognition using key facial features

Frontiers in Computer Science
IntroductionFacial expressions play a crucial role in human emotion recognition and social interaction. Prior research has highlighted the significance of the eyes and mouth in identifying emotions; however, limited studies have validated these claims ...
Ana M. S. Gonzalez-Acosta, Marciano Vargas-Treviño, Patricia Batres-Mendoza, Erick I. Guerra-Hernandez, Jaime Gutierrez-Gutierrez, Jose L. Cano-Perez, Manuel A. Solis-Arrazola, Manuel A. Solis-Arrazola, Horacio Rostro-Gonzalez, Horacio Rostro-Gonzalez   +9 more
doaj   +1 more source

Can Technology Help Promote Equality of Educational Opportunities?

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2016
This chapter assesses the potential for several prominent technological innovations to promote equality of educational opportunities. We review the history of technological innovations in education and describe several prominent innovations, including ...
Brian Jacob, Dan Berger, Cassandra Hart, Susanna Loeb   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Innovations in Microfinance technologies

The Journal of Community Informatics, 2008
An experience to implement PDA technology has been done in Mali, in 2003-2005, to modernize banking operations for a microfinance institution (MFI). This project gave the occasion to experiment the mobile technology, but also the possibility for the poor population to have access to financial services, even if they are far from a large city (rural ...
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Some factors stimulating innovative development of economy

Путеводитель предпринимателя, 2020
In article classifications of innovations are given: grocery and process, technological and not technological. The factors promoting innovations, and the factors braking innovations are considered; types of innovative activity.

doaj  

The impact of innovation on ESG performance [PDF]

Anali Ekonomskog fakulteta u Subotici
Purpose: The main objective of the paper is to explore how different types of innovations contribute to ESG performance in companies. The study aims to distinguish the specific effects of technological and organizational innovations on environmental ...
Popović Biljana, Radivojević Nikola, Popović Aleksandar   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Technological Innovation and Environment Degradation in South Asian Countries

Sir Syed University Research Journal of Engineering and Technology, 2022
This study is an attempt to analyze the impact of technological innovations on Environmental Degradation (ED) in selected South Asian countries over the period 1996 to 2019.
Ayesha Naz, Muhammad Ejaz
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