Results 51 to 60 of about 2,297,325 (306)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A Framework for Market State Prediction with Ontological Asset Selection: A Multimodal Approach

Applied Sciences
In this study, we introduce a detailed framework for predicting market conditions and selecting stocks by integrating machine learning techniques with ontological financial analysis.
Igor Felipe Carboni Battazza, Cleyton Mário de Oliveira Rodrigues, João Fausto L. de Oliveira   +2 more
doaj   +1 more source

The role of external involvement in the creation of management innovations [PDF]

, 2014
There has recently been renewed scholarly interest in management innovating, the creation of new organizational practices, structures, processes and techniques. We suggest that external involvement in the process of management innovating can transpire in
Michael J. Mol, Mol, Michael J., Birkinshaw, J., Birkinshaw, J, Julian Birkinshaw, Mol, M, Birkinshaw, Julian, Mol, Machiel   +7 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The interplay between innovation adoption and pricing competitiveness in Sub-Saharan Africa

International Journal of Innovation Studies
The objective of this work is to evaluate the effects of adopting technological innovation, non-technological innovation, and their complementarity on price competitiveness.
André Dumas Tsambou, Yannick Fosso Djoumessi, Benjamin Fomba Kamga, Simplice A. Asongu   +3 more
doaj   +1 more source

Information Technology Innovation [PDF]

The Permanente Journal, 2008
“Innovation is what distinguishes between a leader and a follower” is a statement often attributed to Apple cofounder Steve Jobs. Nowhere is this saying truer than in the realm of information technology (IT), where the blistering pace of change can make even casual observers dizzy. Yet IT innovation can be a two-edged sword.
openaire   +2 more sources

Technological Innovations to Tackle Health Inequalities in Cancer Care

People affected by cancer or at risk of cancer must be able to access health information and/or healthcare services in an equitable manner to bring about a timely response.
Papadopoulou, Constantina, Marshall-Mckenna, Rebecca, Kotronoulas, Grigorios, Wang, Tongyao   +3 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The first look: a biometric analysis of emotion recognition using key facial features

Frontiers in Computer Science
IntroductionFacial expressions play a crucial role in human emotion recognition and social interaction. Prior research has highlighted the significance of the eyes and mouth in identifying emotions; however, limited studies have validated these claims ...
Ana M. S. Gonzalez-Acosta, Marciano Vargas-Treviño, Patricia Batres-Mendoza, Erick I. Guerra-Hernandez, Jaime Gutierrez-Gutierrez, Jose L. Cano-Perez, Manuel A. Solis-Arrazola, Manuel A. Solis-Arrazola, Horacio Rostro-Gonzalez, Horacio Rostro-Gonzalez   +9 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source