Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Framework for Market State Prediction with Ontological Asset Selection: A Multimodal Approach
In this study, we introduce a detailed framework for predicting market conditions and selecting stocks by integrating machine learning techniques with ontological financial analysis.
Igor Felipe Carboni Battazza +2 more
doaj +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The interplay between innovation adoption and pricing competitiveness in Sub-Saharan Africa
The objective of this work is to evaluate the effects of adopting technological innovation, non-technological innovation, and their complementarity on price competitiveness.
André Dumas Tsambou +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The role of external involvement in the creation of management innovations [PDF]
There has recently been renewed scholarly interest in management innovating, the creation of new organizational practices, structures, processes and techniques. We suggest that external involvement in the process of management innovating can transpire in
Michael J. Mol +7 more
core +1 more source
The first look: a biometric analysis of emotion recognition using key facial features
IntroductionFacial expressions play a crucial role in human emotion recognition and social interaction. Prior research has highlighted the significance of the eyes and mouth in identifying emotions; however, limited studies have validated these claims ...
Ana M. S. Gonzalez-Acosta +9 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Technological Innovations to Tackle Health Inequalities in Cancer Care
People affected by cancer or at risk of cancer must be able to access health information and/or healthcare services in an equitable manner to bring about a timely response.
Papadopoulou, Constantina +3 more
core +1 more source
Experience with the management of technological innovations within the Australian construction industry [PDF]
The BRITE Project (Building Research Innovation Technology and Environment) was established by the Australian Cooperative Research Centre for Construction Innovation to encourage and report on innovative developments in the construction industry.
Miller, Graham +3 more
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