Results 91 to 100 of about 33,344 (264)

Economic mechanisms of structural transformations and technological leadership in economy

Векторы благополучия: экономика и социум
The article examines economic mechanisms aimed at accelerating innovative sustainable development and achieving technological leadership in the national economy.
E.A. Gasanov, M.A. Gasanov, V.S. Zhironkin, T.G. Krasota   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Digital ecosystem as a driver of Russia’s technological leadership: conceptual approaches and implementation mechanisms

Вестник университета
A comprehensive analysis of digital ecosystem as a key factor in achieving technological leadership of Russia in the context of global competition has been carried out.
E. A. Karelina, V. S. Sidorenko
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Intelligent Maturity of Russia's Regional Economy: Assessment and Measures for Regulatory and Infrastructural Support of the Industry 5.0 Innovation Environment

Управленческое консультирование
The article analyses the process of forming the intelligent and digital maturity of Russia's regional economy in the context of the transition to the technological paradigm of Industry 5.0.
A. V. Babkin, E. V. Shkarupeta, I. A. Babkin   +2 more
doaj  

Legal Issues of Ensuring Technological Sovereignty

Journal of Digital Technologies and Law
Objective: to identify the legal issues of ensuring technological sovereignty and to determine scientifically grounded vectors of their solution.Methods: the study is based on formal-legal, historical-legal, comparative legal methods, as well as the ...
M. V. Zaloilo
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Monitoring regional technological development and sovereignty: an organizational mechanism

Ekonomika Nauki
The article reveals the specifics of organizing technological development monitoring at the regional level, considering the goals and objectives of national development in the technological sphere, as well as the need to create clarifying indicative ...
N. A. Kulagina, V. V. Garipova
doaj  

Vavilov’s law in the era of next-generation sequencing: answers, puzzles, hints

Труды по прикладной ботанике, генетике и селекции
Since N. I. Vavilov’s report in Saratov on June 4, 1920, the Law of Homologous Series in Hereditary Variation has not only found practical application in the targeted search for new sources for breeding, but also played an important role in the ...
E. K. Khlestkina
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source