Results 111 to 120 of about 47,818 (311)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Вестник университетаA comprehensive analysis of digital ecosystem as a key factor in achieving technological leadership of Russia in the context of global competition has been carried out.
E. A. Karelina, V. S. Sidorenko
doaj +1 more source
Understanding Leadership A Coordination Theory [PDF]
Important aspects of leadership behavior can be rendered intelligible through a focus on coordination games. The concept of common knowledge is shown to be particularly important to understanding leadership.
Nicolai J. Foss
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Legal Issues of Ensuring Technological Sovereignty
Journal of Digital Technologies and LawObjective: to identify the legal issues of ensuring technological sovereignty and to determine scientifically grounded vectors of their solution.Methods: the study is based on formal-legal, historical-legal, comparative legal methods, as well as the ...
M. V. Zaloilo
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Vavilov’s law in the era of next-generation sequencing: answers, puzzles, hints
Труды по прикладной ботанике, генетике и селекцииSince N. I. Vavilov’s report in Saratov on June 4, 1920, the Law of Homologous Series in Hereditary Variation has not only found practical application in the targeted search for new sources for breeding, but also played an important role in the ...
E. K. Khlestkina
doaj +1 more source
From crisis leadership to digital and inclusive leadership in the aftermath of the pandemic [PDF]
The sudden closure of educational institutions amid the pandemic compelled school administrators to manage the crisis with little reaction time. Despite the stringent and exigent predicament, school principals had to amend and modify their leadership ...
Fernández Prados, Juan Sebastián +2 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Indonesian Interdisciplinary Journal of Sharia EconomicsThis study aims to analyze the influence of transformational leadership and technological innovation on the performance of Jember Regency Inspectorate employees, with organizational culture as an intervening variable.
Siti Mualfa +2 more
doaj +1 more source