Results 121 to 130 of about 47,818 (311)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Impact of economic digital transformation on technologically leading enterprises development

E-Management
In modern economy, technological leadership and digital technologies are becoming key factors of development both at the global level and at the level of individual countries and territories. The purpose of the study is to systematize business strategies
V. V. Spitsyn, M. A. Gasanov, V. A. Leonova   +2 more
doaj   +1 more source

Environmental Leadership Program (ELP)

This webpage provides an overview of the Environmental Leadership Program.  The Environmental Leadership Program (ELP) is a non-profit center for leadership development within the environmental field; it addresses the leadership development and training

core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Tight cultures as a double-edged sword for burnout: the job demands-resources perspective on perceived organizational tightness and the moderating effect of gender

Frontiers in Psychology
IntroductionAlthough research on cultural tightness—the extent to which groups enforce strict norms and tolerate few deviations—reveals mixed effects on wellbeing, most existing evidence comes from national or regional contexts.
Shota Kawasaki, Xi Zou
doaj   +1 more source

Market integration and technological leadership in Europe

, 2010
This study traces and analyses the changes in firm and industry structure due to EU market integration and the integration of the EU in the global economy. It focuses on changes in competitiveness based on innovation and technology development. The study
Belderbos, Rene, Sleuwaegen, Leo, Veugelers, Reinhilde   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Intelligent Maturity of Russia's Regional Economy: Assessment and Measures for Regulatory and Infrastructural Support of the Industry 5.0 Innovation Environment

Управленческое консультирование
The article analyses the process of forming the intelligent and digital maturity of Russia's regional economy in the context of the transition to the technological paradigm of Industry 5.0.
A. V. Babkin, E. V. Shkarupeta, I. A. Babkin   +2 more
doaj  

Navigating Complexity: Strategies for Developing 'Fit for Purpose' Leadership in Contemporary Higher Education

International Journal of Applied Research in Business and Management
In an era marked by rapid technological advancements and evolving societal demands, higher education institutions face unprecedented complexity in leadership.
Mabasa Fumani Donald, Doreen Morukhu
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source