Results 91 to 100 of about 7,527,785 (272)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Research Trends & Emerging Technologies for Genealogists [PDF]
, 2016 This study examines current research methods utilized by genealogists, and seeks to discover the impact of emerging tools and technologies on their information seeking needs and behaviors.
Lucy, Catherine
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Emerging aerospace technologies [PDF]
The United States Government has a long history of promoting the advancement of technology to strengthen the economy and national defense. An example is NASA, which was formed in 1958 to establish and maintain U.S. space technology leadership.
Ballhaus, W. F., Jr., Milov, L. A.
core +1 more source
New technologies in general aviation [PDF]
, 2010 This research explored the technological needs of GA pilots at international levels. Overall, single pilot operators tend to value costs as the most important feature of any technology, followed by technology that helps with pre-flight tasks as well as
Diaz Vilela, Luis +2 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Ensuring development of business and support of an enterprise initiative
Ученые записки Российской академии предпринимательства, 2021 In the article questions and problems of providing entrepreneurs and enterprise structures by available and acceptable financial (credit) resources (means), ensuring steady and reliable work of a banking system of the country, features of the ...
D. A. Zuravlev, E. I. Akhmetova
doaj
Advanced interdisciplinary technologies [PDF]
The following topics are presented in view graph form: (1) breakthrough trust (space research and technology assessment); (2) bionics (technology derivatives from biological systems); (3) biodynamics (modeling of human biomechanical performance based on ...
Anderson, John L.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source