Results 101 to 110 of about 7,354,647 (255)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging aerospace technologies [PDF]
The United States Government has a long history of promoting the advancement of technology to strengthen the economy and national defense. An example is NASA, which was formed in 1958 to establish and maintain U.S. space technology leadership.
Ballhaus, W. F., Jr., Milov, L. A.
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Ukraine's Customs Services and the Need for Reform
Recoletos Multidisciplinary Research JournalThe article examines the need to introduce systemic changes in the customs service of Ukraine, caused by present-day challenges and requirements. The authors focus on the key factors that stipulate transformation, such as integration into the European ...
Iryna Sopilko +4 more
doaj +1 more source
Advanced interdisciplinary technologies [PDF]
The following topics are presented in view graph form: (1) breakthrough trust (space research and technology assessment); (2) bionics (technology derivatives from biological systems); (3) biodynamics (modeling of human biomechanical performance based on ...
Anderson, John L.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Research Trends & Emerging Technologies for Genealogists [PDF]
, 2016 This study examines current research methods utilized by genealogists, and seeks to discover the impact of emerging tools and technologies on their information seeking needs and behaviors.
Lucy, Catherine
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Вестник Российского экономического университета имени Г. В. ПлехановаThe article analyzes the condition of human capital in the agrarian sector in the Republic of Belarus in view of its continuous development and sustainable growth.
T. A. Tsetsiarynets
doaj +1 more source