Results 231 to 240 of about 4,155,604 (307)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Technology-Based Interventions for Prevention of Type 2 Diabetes Following Gestational Diabetes: Systematic Review and Meta-Analysis.

J Med Internet Res
Eades C, Nguyen-Hoang A, Hoyle L, Cameron D, Evans JM.   +4 more
europepmc   +1 more source

Technology-based sports training informed workshops and physical education teachers' job satisfaction, commitment, and self-determined motivation. [PDF]

BMC Psychol
Tian H, Liu Q, Wang Q.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

An Investigation into the Accuracy of LiDAR Technology for In-Home Rehabilitation Planning: A Proof-of-Concept Study

Mansoubi M, Silva-Magalhães TD, Bassitt J, Lamb S, Massey G, Haron A, Cooper G, Evangelidis P, Weightman A, Ezekiel L, Dennison L, Corser J, Coles-Kemp L, Bradbury K, Dawes H.   +14 more
europepmc   +1 more source

Navigating Virtual Reality in Stroke Rehabilitation: Scoping Review of Diverse Intervention Effects.

JMIR Serious Games
Liu R, Lin B, Zhai Y, Wang W.
europepmc   +1 more source

A comparative analysis of health technology assessment decision-making for cancer drugs in Germany and England. [PDF]

Front Public Health
He J, Wei H, Mo Q, Liu Y, Li X, Yang Y, Tian L.   +6 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Past, present, and future of virtual reality-based biological science education (2010-2025): a BERTopic-driven analysis. [PDF]

BMC Med Educ
Xian J, Wu JG.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source