Results 71 to 80 of about 21,474,219 (234)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

“Because he drives electric, I will too”: the impact of celebrities in advertising on consumer acceptance of electric vehicles

Frontiers in Communication
Celebrity endorsement is a common advertising strategy and is increasingly used to promote technological innovations, such as electric vehicles. Despite growing attention and promotional efforts, public acceptance of this technology remains limited ...
Anika Herzig
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Acceptance Of Internet Banking In Iran: Extension of Technology Acceptance Model (TAM)

Iranian Journal of Information Processing & Management, 2009
In the past several decades, perception of usefulness and ease of use had been the most important factors in recognition of new technologies in the field of information systems.
Muhammad Ali Bagheri, Muhammad Taghi Hamidi Beheshti, Sirous Alidousti   +2 more
doaj  

TECHNOLOGY ACCEPTANCE AND LEARNING MOTIVATION IN CALL AND MALL: A QUANTITATIVE STUDY EXTENDING TAM IN INDONESIAN VOCATIONAL HIGH SCHOOLS

English Review: Journal of English Education
This quantitative study examined technology acceptance and learning motivation in Computer-Assisted Language Learning (CALL) and Mobile-Assisted Language Learning (MALL) environments by extending the Technology Acceptance Model (TAM) with motivational ...
Masfufah Zahiroh, Slamet Asari
doaj   +1 more source

Pengaruh Kemudahan Penggunaan dan Manfaat yang Dirasakan terhadap Sikap dan Niat Pembelian Online (Studi pada Pembelian Batik di Jawa Timur)

Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 2012
The design of this study are included in the confirmatory research and research as well as explanatory. Analysis technique used is to use the Structural Equation Modeling (SEM)..
R. Andi Sularso
doaj   +1 more source

Demographic differences and internet banking acceptance [PDF]

, 2011
This research contributes to additional understanding of TAM’s validity in Internet banking acceptance. Although some user profile variables have been examined in technology acceptance research, there has been little research investigating the new roles ...
Li, Honglei, Lai, Min Mei
core  

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source