Results 81 to 90 of about 5,896,949 (323)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

STEM: Science, Technology, Engineering and Math [PDF]

, 2013
Science is on our minds at Linfield. Students and faculty spent the summer collaborating on research in the sciences, mathematics and technology, both here and ...
Davis, Laura, Mileham, Mardi
core   +1 more source

A framework for design engineering education in a global context [PDF]

, 2010
This paper presents a framework for teaching design engineering in a global context using innovative technologies to enable distributed teams to work together effectively across international and cultural boundaries.
Ade Mabogunje, Andrew J. Wodehouse, Bates, Caroline Breslin, Eris, Grierson, Hilary J. Grierson, Larry J. Leifer, Love, Mills, Ozgur Eris, Prosser, Twigg, William J. Ion   +13 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Redesigning the internal spaces of the Saudi housing is an educational necessity for the role of the family in achieving Vision 2030

Journal of Architecture, Art & Humanistic Science
Education is one of the means of building and developing peoples, and one of the causes of progress and advancement...and the first thing that God revealed to His Profet, And university education in its stages Various of the highest levels of learning ...
Assist. Prof. Dr. Doaa Abdel Salam Hassan M. Salem Associate Professor Faculty of Engineering and Information Technology - Onaizah Private Colleges – KSA
doaj   +1 more source

Research on management and application of tunnel engineering based on BIM technology

Journal of Civil Engineering and Management, 2019
The emergence of BIM technology has provided powerful technical means for realizing informatization and digitization in the field of engineering construction, which remarkably promotes the transformation and advance of production and management modes in ...
ZhanPing Song, GuiLin Shi, JunBao Wang, HaiMin Wei, Tao Wang, GuanNan Zhou   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A recent visit by the Editor-in-Chief of npj Quantum Materials - Nature to the Vietnam Journal of Science, Technology, and Engineering (VJSTE)

Vietnam Journal of Science, Technology and Engineering
On August 8, 2024, Professor Sang-Wook Cheong, Editor-in-Chief of npj Quantum Materials - Nature, and Professor Manh-Huong Phan from the University of South Florida visited the Vietnam Journal of Science, Technology and Engineering (VJSTE). This meeting
The Vietnam Journal of Science, Technology and Engineering
doaj