Results 91 to 100 of about 1,089,166 (296)

Data diaries: Self-reported chronicles on online health platforms and the challenges for technology assessment

open access: yesTATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis
This research article explores the ethical, social, and economic implications of online health platforms that promote participatory models of data collection and use.
Dana Mahr
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors

open access: yesIEEE Access
Implementing Information and Communication Technologies (ICTs) in the healthcare sector faces several barriers, and the pace of adoption may vary depending on several factors, including individual attributes such as competence and experience, along with ...
Abey Jose   +7 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Benefits and Challenges of California Offshore Wind Electricity: An Updated Assessment

open access: yesEnergies
Offshore wind (OSW) technology has recently been included in California’s plans to achieve 100% carbon-free electricity by 2045. As an emerging technology, many features of OSW are changing more rapidly than established renewable options and are shaped ...
Adam Rose   +5 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

How Will the Railway Look Like in 2050? A Survey of Experts on Technologies, Challenges and Opportunities for the Railway System

open access: yesIEEE Open Journal of Intelligent Transportation Systems
The railway system can fulfil society’s current and future transportation goals; compared to other transport modes, it does that with high energy, space and resource efficiency.
Michael Nold, Francesco Corman
doaj   +1 more source

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