Results 71 to 80 of about 4,522,828 (308)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Demokratisierung von Technik ohne Wirtschaftsdemokratie?

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2020
Der vorliegende Beitrag diskutiert vor dem Hintergrund der gegenwärtigen Dominanz ökonomischer Akteure in der Entwicklung und dem Einsatz von Technik, inwiefern das Einstehen der Technikfolgenabschätzung (TA) für eine demokratische Gestaltung des ...
Philipp Frey, Christoph Schneider, Christian Wadephul   +2 more
doaj   +1 more source

Attitudes of patients toward adoption of 3D technology in pain assessment: Qualitative perspective [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. © Fotios Spyridonis, Gheorghita Ghinea, Andrew O Frank. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 10.04.2013.
Frank, AO, Ghinea, G, Spyridonis, F
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Technology education teacher development in solomon islands: Enhancing teachers’ perceptions and classroom practices [PDF]

, 2007
Technology education in the Solomon Islands is in the process of change with the curriculum being developed into a more broad technological literacy approach, comprising of technological knowledge, technological practices, and the nature of technology ...
Jones, Alister, Moreland, Judy, Sade, David   +2 more
core   +1 more source

Systematic review of economic evaluations of laparoscopic surgery for colorectal cancer [PDF]

, 2008
Objective Colorectal cancer is one of the most common cancers and the standard surgical treatment for this cancer is open resection (OS), but laparoscopic surgery (LS) may be an alternative treatment.
Aberdeen Health Technology Assessment Group, De Verteuil, Robyn, Fraser, Cynthia Mary, Hernández, Rodolfo Andrés, Vale, Luke David   +4 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Responsible AI in Farming: A Multi-Criteria Framework for Sustainable Technology Design

Applied Sciences
The continuous fusion of artificial intelligence (AI) and autonomous farming machinery (e.g., drones and field robots) provides a significant shift in the daily work experience of farmers.
Kevin Mallinger, Ricardo Baeza-Yates
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source