Results 61 to 70 of about 1,293,738 (268)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dr. Seltsam, oder wie ich lernte, die Drohne zu lieben

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Drohnen werden inzwischen in vielen und sehr unterschiedlichen Kontexten verwendet. Aus dem Blickwinkel der Technikfolgenabschätzung scheint es daher sinnvoll, den Umfang der momentanen und zukünftigen Nutzung von Drohnen und daraus resultierende ...
Karsten Weber, Bernhard Rinke, Christian Alwardt   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Technikfolgenabschätzung als technikwissenschaftliche Disziplin?

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Aufgrund ihrer Methode wie auch Forschungspraxis kann die Technikfolgenabschätzung (TA) als eine Teildisziplin der Technikwissenschaften angesehen werden kann.
Klaus Kornwachs
doaj   +1 more source

Synergism in Technology Assessment [PDF]

International Journal of Technology Assessment in Health Care, 1989
In 1899, Charles H. Duell, Commissioner of the U.S. Office of Patents, urged President McKinley to abolish the Patent Office by saying, “Everything that can be invented has been invented.” Fortunately for the health care industry, there have been more significant “medical inventions” in the 89 years following Duell's utterance than in all of recorded ...
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-arm RCT

Health Technology Assessment, 2018
Background: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment.
Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham, Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, Sabu Oomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Macharouthu, Pranathi Ramachandra, Vivek Pattan, John Sykes, Valerie Curran, Cornelius Katona, Tom Dening, Martin Knapp, Renee Romeo, Richard Gray   +25 more
doaj   +1 more source

Theorie der Technikfolgenabschätzung reloaded

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Vor etwa zehn Jahren identifizierte eine aufflackernde Debatte die Charakteristika Folgenorientierung, Beratungsbezug und Wissenschaftlichkeit als mögliche Eckpfeiler einer Theorie der Technikfolgenabschätzung (TA).
Stefan Böschen, Ulrich Dewald
doaj   +1 more source

Interoperability Technology Assessment

Electronic Notes in Theoretical Computer Science, 2002
AbstractInteroperability between heterogeneous computer systems is vital to many types of enterprise applications where pressing new requirements may arise quickly and change rapidly. Achieving interoperability, however, is a complex task involving a delicate mixture of cooperation and competition.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source