Results 51 to 60 of about 13,591,223 (317)

Assessment, Technology, and Change [PDF]

Journal of Research on Technology in Education, 2010
Despite three decades of advances in information and communications technology (ICT) and a generation of research on cognition and new pedagogical strategies, the field of assessment has not progressed much beyond paper-andpencil item-based tests. Research has shown these instruments are not valid measures of sophisticated intellectual performances ...
Clarke, Jody, Dede, Christopher
openaire   +3 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Technology assessment in medicine

Academic Medicine, 1992
The author defines the concepts medical technology and technology assessment and presents a paradigm for the evaluation of medical technologies. He proposes a hierarchical assessment scheme in which level I, biologic plausibility, compares the technology's proposed mode of action with current biologic information and theory.
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Moulded cast compared with K-wire fixation after manipulation of an acute dorsally displaced distal radius fracture: the DRAFFT 2 RCT

Health Technology Assessment, 2022
Background: Patients with a displaced fracture of the distal radius are frequently offered surgical fixation. Manipulation of the fracture and moulded plaster casting is an alternative treatment that avoids metal implants, but evidence of its ...
Matthew L Costa, Juul Achten, Alexander Ooms, May Ee Png, Jonathan Cook, Melina Dritsaki, Sarah E Lamb, Robin Lerner, Kylea Draper, Marta Campolier, Helen Dakin, Alwin McGibbon, Nicholas Parsons, Helen Hedley, Joseph Dias, the DRAFFT 2 Collaborators   +15 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

CAF and CAMM analyses on the first 10 years of national Kanta services in Finland

Finnish Journal of eHealth and eWelfare, 2020
We report the large-scale deployment, implementation and adoption of the nationwide centralized integrated and shared Kanta health information services by using the Clinical Adoption Framework (CAF).
Vesa Jormanainen, Jarmo Reponen
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Demokratie und Technikfolgenabschätzung

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2020
Technikfolgenabschätzung (TA) ist vor über 50 Jahren zur Unterstützung demokratischer Meinungsbildung und Entscheidungsfindung entstanden. Sie hat sich seitdem in demokratischen Gesellschaften westlichen Typs weiterentwickelt und diversifiziert.
Armin Grunwald, Thomas Saretzki
doaj   +1 more source