Results 91 to 100 of about 4,522,828 (308)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A review of NASA-sponsored technology assessment projects [PDF]

Recent technology assessment studies sponsored by NASA are reviewed, and a summary of the technical results as well as a critique of the methodologies are presented.
Alexander, A. D., III, Mascy, A. C., Wood, R. D.   +2 more
core   +1 more source

Exploring creativity and progression in transition through assessment is for learning [PDF]

, 2007
This paper provides an overview of the aims, methods and findings of the Capability and Progression in Transition through Assessment for Learning in Design and Technology (CAPITTAL-DT) project.
Bain, Jenny, McLaren, Susan V., Stables, Kay   +2 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Transforming Telemedicine: Strategic Lessons and Metrics from Italy’s Telemechron Project (Telemechron Study)

Technologies
Background: The Telemechron project addresses critical needs in telemedicine by evaluating technology assessment frameworks and key performance indicators (KPIs), among other objectives.
Sara Jayousi, Martina Cinelli, Roberto Bigazzi, Stefano Bianchi, Simonetta Scalvini, Gabriella Borghi, Palmira Bernocchi, Sandro Inchiostro, Alexia Giovanazzi, Marina Mastellaro, Maria Adalgisa Gentilini, Lorenzo Gios, Mauro Grigioni, Carla Daniele, Giuseppe D’Avenio, Sandra Morelli, Daniele Giansanti   +16 more
doaj   +1 more source

HTA und aktuelle Herausforderungen: Harmonisierung, Real World Data und Surrogatparameter

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2018
Health Technology Assessment is one of the standard instruments in support of the decision-making to define the public health services both internationally and in the German health care system.
Rüther, Alric, Herrmann, Kirsten H., Hebborn, Ansgar, Perleth, Matthias, Schwarzer, Ruth, Schürmann, Christoph, Sieben, Wiebke, Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm, Schramm, Wendelin   +11 more
doaj   +1 more source

Technology assessment of portable energy RDT and P, phase 1 [PDF]

A technology assessment of transportation energy research, development, technology, and production was undertaken to assess the technical, economic, environmental, sociopolitical issues associated with transportation energy options, and to determine ...
Spraul, J. R.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Using Technology to Support Success: Assessing Value Using Strategic Academic Research and Development

Education Sciences
This study explores the impact of educational technology on student success within higher education institutions (HEIs). Faced with pressures to improve enrollment, retention, and graduation rates, HEIs have increasingly turned to technology solutions ...
Rebecca Torstrick, Joseph Finke
doaj   +1 more source