Results 131 to 140 of about 1,567,434 (318)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Knowledge and cognitive process dimensions of Technology teachers' lesson objectives

open access: yesSouth African Journal of Education, 2014
A clearly stated lesson objective is considered an essential component of a well-planned lesson. Many teachers of Technology, a relatively new subject in South African schools, teach Technology with rather limited training both in content and ...
David Mathumbu   +2 more
doaj  

Investigating the Effects of Different Distance Learning Modalities on Student Academic Performance in Technology Education Programs

open access: yesVietnam Journal of Education
The rise of online distance learning has necessitated investigations into its effectiveness across various educational contexts. This study examines the academic performance of students enrolled in technology education programs across three distinct ...
Michael Calago   +3 more
doaj   +1 more source

Reflecting on the development of a new school subject: the development of technology education in New Zealand.

open access: yes, 2007
The last 10 years have seen the production of curricula in Australia, the United Kingdom, USA, Canada, Hong Kong and New Zealand that emphasise the importance of students developing technological literacy.
Jones, Alister
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Comparing perspectives: comparative research in technology education.

open access: yes, 2005
This paper reflects on a number of different ways by which comparative research in technology education has been undertaken across countries. The history of comparative research in technology education demonstrates that it is possible to identify three ...
Pavlova, Margarita
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

IMPROVING AWARENESS OF INTERNET SECURITY AND ETHICS AMONG STUDENTS AT SMA NEGERI 2 MRANGGEN

open access: yesJurnal Layanan Masyarakat (Journal of Public Services)
This community service initiative aimed to enhance the awareness of internet security and ethics among high school students at SMA Negeri 2 Mranggen, Demak Regency, Central Java.
Muhammad Naufal   +3 more
doaj   +1 more source

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