Results 71 to 80 of about 1,567,434 (318)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Editorial

LUMAT
When we started to prepare this first LUMAT special issue on technology education in early 2023 we were a bit concerned whether our rather broad framing of the topic – contemporary issues – would attract too much attention.
Johanna Naukkarinen, Sonja Niiranen
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

STEM or STEAM?: the Critical Role of Arts in Technology Education (and the Critical Role of Art in Technology)

Irish Journal of Academic Practice, 2020
This paper outlines the interdependency between arts and technology, and explains the absolute necessity of keeping them together in our education systems.
Etain Watson
doaj   +1 more source

Technologies for engineering education [PDF]

Australian Journal of Multi-Disciplinary Engineering, 2013
AbstractWithin any discipline, teaching involves a distinctive relationship between content, pedagogical approaches and the use of technologies. In engineering education, the content includes mathematical symbolic and diagrammatic forms, traditionally taught using handwritten and talk-based approaches which have not been easily accommodated by keyboard-
P. Maclaren, S. Singamemni, D.I. Wilson
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Indigenous Knowledge Integration in South Africa’s Technology Education Curriculum: Current Status, Challenges, and Future Directions [PDF]

Journal of Education and Learning Technology
This position paper critically evaluated the integration of indigenous knowledge into the South African Technology Education curriculum. Using a robust theoretical framework, it compared the historical significance of indigenous practices with the ...
Benjamin Seleke, Nixon J.P. Teis, Christo J. Els, Glen Legodu   +3 more
doaj   +1 more source

The need to consider the predictive capacity of intelligence and its malleability within design and technology education research. [PDF]

, 2020
General intelligence is a fundamental human capacity with significant educational implications. However, it is often not considered in educational research despite substantial evidence illustrating its association with positive life outcomes and ...
Buckley, Jeffrey
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fostering creativity and curiosity through technological problem-solving

LUMAT
The selection of the topic of this special issue “Fostering creativity and curiosity through technological problem-solving” was inspired by John Dakers’ editorial in the previous LUMAT technology education special issue.
Sonja Niiranen, Johanna Naukkarinen
doaj   +1 more source