Results 51 to 60 of about 7,784,138 (308)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The design of vertical R&D collaborations [PDF]

, 2009
Suppliers play a major role in innovation processes. We analyze ownership allocations and the choice of R&D technology in vertical R&D cooperations. Given incomplete contracts on the R&D outcome, there is a tradeoff between R&D specifically designed ...
Herbst, Patrick, Walz, Uwe
core  

Pathway to the PiezoElectronic Transduction Logic Device

, 2015
The information age challenges computer technology to process an exponentially increasing computational load on a limited energy budget - a requirement that demands an exponential reduction in energy per operation.
Armstrong, C., Bryce, B. A., Copel, M., Elmegreen, B. G., Gordon, M. S., Haensch, W., Hung, L. -W., Keech, R., Kuroda, M. A., Liu, X. -H., Martyna, G. J, Miyazoe, H., Newns, D. M., Reuter, K. B., Rossnagel, S. M., Schrott, A. G., Shaw, T. M., Shett, S., Solomon, P. M., Theis, T. N., Trolier-McKinstry, S.   +20 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

General aviation technology program [PDF]

The research and technology program of the civil air transportation system is reported. Research is discussed for stall/spin, crashworthiness, pilot operations, flight efficiency, propulsion, and ...

core   +1 more source

Teacher change in a developing curriculum area: the example of trade teachers in the New Zealand technology curriculum [PDF]

, 2000
Technology education for all students is a relatively new phenomenon in national and international curricula. Although New Zealand has a long history of technical education in the senior primary and secondary school, a curriculum for technology education
Ewington, Louis, Jones, Alister
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

THE TECHNOLOGY OF THE INTEGRAL SCIENTIFIC ACTIVITIES

Sovremennye Issledovaniâ Socialʹnyh Problem, 2014
Based on complete-approach of kompletiks formulated the principle of the integrity of the technology research activities and created a general model of the complex technology of research activities, ranging from the formation of technology design and ...
Marat Makhmetovich Telemtaev, Nurakhov Nurlanovich Nurzhan, Shiganova Maratovna Giulnara   +2 more
doaj   +1 more source

Q & A on Customized Employment: Assistive Technology as a Workplace Support [PDF]

, 2005
[Excerpt] Despite the promise of assistive technology, many people with significant physical disabilities remain in facility-based employment programs. Underutilization of AT to facilitate competitive employment is related to a number of critical issues.
Office of Disability Employment Policy
core   +1 more source