Results 71 to 80 of about 20,845,308 (265)

General Electric Atomic Power Reports [PDF]

open access: yes, 1964
From introduction: "Summary report of the 1000 MWe Boiling Water Reactor Plant Feasibility Study performed by the General Electric Company.
General Electric Company
core  

Information Technology in General Practice: current use and views on future development

open access: yesJournal of Innovation in Health Informatics, 1997
Objective: To ascertain general practitioners current use of computers and their views on future development of information technology in general practice. Design: Postal questionnaire sent to general practitioners.
Arfan Ahmed, Anita Berlin
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Contraloría General

open access: yes, 2012
146 p.
Contraloría General, Contraloría General
core   +1 more source

Research on General Scheme Technology of FXD3-J EMUs Car

open access: yes机车电传动, 2019
The CR200J power concentrated EMUs are power concentrated EMUs, developed to enhance the comfort of China's railway general speed train passengers and the transportation capacity of passenger dedicated lines.
Wei WANG, Shoujun YANG, Jingqi WANG
doaj  

General studies, information and communication technology and contemporary mission in Africa

open access: yesHTS Teologiese Studies/Theological Studies
This study examines the relationship between general studies, information and communication technology (ICT), and contemporary evangelism in Nigeria.
Christopher N. Ibenwa   +2 more
doaj   +1 more source

NANOTECHNOLOGY AN EMERGING NEW TECHNOLOGY FOR INDONESIA PART I. NANOTECHNOLOGY IN GENERAL

open access: yesReaktor, 2006
Nanotechnology is shortly defined as the ability to build micro and macro material and product with atomic precistion. Feynman is considered to be the scientist who put a strong foundation for the development of nanotechnology with his phenomenal speech ...
Ratnawati Ratnawati   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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